Publications by authors named "Hedwika Nastiti"
Article Synopsis
- - Familial Reactive Perforating Collagenosis (FRPC) is a rare, benign skin condition primarily seen in young children, with fewer than 50 documented cases, and its causes and treatments remain unclear.
- - A case study of a 20-year-old male from Indonesia showed multiple skin papules across his body for over 7 years, and similar symptoms were present in his family.
- - The patient was successfully treated with a topical corticosteroid, desoximetasone, leading to significant improvement in skin lesions, suggesting corticosteroids could be a viable treatment for FRPC.
Epithelial mast cells are generally present in the airways of patients with allergic asthma that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic airway inflammation and contribute directly to the main symptoms of allergic patients. Phosphodiesterase 3 (PDE3) tailors signaling of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are critical intracellular second messenger molecules in various signaling pathways.
View Article and Find Full Text PDFPhosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans. Case reports showed that enoximone, which is a smooth muscle relaxant that inhibits PDE3, is beneficial and lifesaving in status asthmaticus and is well tolerated.
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