Publications by authors named "Hedele Zeng"
Article Synopsis
- Sprouting angiogenesis is crucial for processes like organ development and healing, with mesenchymal stem cells (MSCs) playing a key role due to their ability to enhance blood vessel formation through interaction with endothelial cells.
- A new 3D in vitro model, microvessel-on-a-chip, was developed to analyze the interactions between human umbilical vein endothelial cells (HUVECs) and MSCs, where MSCs were found to smooth microvessel surfaces and extend angiogenic sprouts.
- Findings revealed that MSCs preferentially positioned themselves around specific areas of the microvessels, contributing to the activation and stabilization of new capillary structures in the engineered tissue model.
Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs' micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively.
View Article and Find Full Text PDFDespite that microfluidic paper-based analytical devices (μPADs) provide effective analytical platforms for point-of-care diagnosis in resource-limited areas, it remains challenging to achieve simple and low-cost fabrication of μPADs. A novel method for fabrication of μPADs is developed in this study using a folded polydimethylsiloxane (PDMS)-coated paper mask with a specific pattern to form a sandwich structure with inserted chromatographic paper. PDMS penetrates the target paper from the front and the back sides, and then is cured in the target paper to form legible channels.
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