Publications by authors named "Hector J Nunez-Medina"
Article Synopsis
- The study aimed to determine if selecting oral antiplatelet drugs based on a patient's genotype using a clinical decision support algorithm can lower the rate of major adverse cardiovascular and cerebrovascular events among Caribbean Hispanic patients following treatment.
- Conducted as an open-label, multicenter, non-randomized trial across eight hospitals in Puerto Rico, it involved 300 patients who received percutaneous coronary intervention and were divided into standard-of-care and genotype-guided groups.
- Results indicated that although the genotype-guided group had a lower risk of major adverse events compared to the standard group (8.7% vs 10.7%), the difference was not statistically significant.
Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program.
Dagmar F Hernandez-Suarez Jonnalie C Tomassini-Fernandini Angelica Cuevas Anyelis N Rosario-Berrios Héctor J Nuñez-Medina
Int J Environ Res Public Health
May 2018
Variations in several clopidogrel-pharmacogenes have been linked to clopidogrel response variability and clinical outcomes. We aimed to determine the frequency distribution of major polymorphisms on , , and pharmacogenes in Puerto Ricans. : This was a cross-sectional, population-based study of 200 unrelated "Guthrie" cards specimens from newborns registered in the Puerto Rican newborn screening program (PRNSP) between 2004 and 2014.
View Article and Find Full Text PDF