Publications by authors named "Hector Ibanez"

Axon guidance molecules are frequently altered in pancreatic ductal adenocarcinoma (PDA) and influence PDA progression. However, the molecular mechanism remained unclear. Using genetically engineered mouse models to examine semaphorin 3D (SEMA3D), we identified a dual role for tumor- and nerve-derived SEMA3D in the malignant transformation of pancreatic epithelial cells and invasive PDA development.

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Article Synopsis
  • Axon guidance molecules, particularly semaphorin 3D (SEMA3D), are significantly altered in pancreatic ductal adenocarcinoma (PDA), but their role in tumor development remains unclear.
  • Using genetically engineered mouse models, researchers discovered that tumor-derived SEMA3D contributes to the malignant transformation of pancreatic cells, while nerve-derived SEMA3D plays a pivotal role in PDA development.
  • Findings suggested that SEMA3D impacts macrophage polarization in the tumor environment, promoting a pro-tumorigenic M2 state through lactate signaling, indicating a complex interaction between tumor and nerve-derived factors in PDA progression.
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The Per-Arnt-Sim (PAS; named for the representative proteins: Period, Aryl hydrocarbon receptor nuclear translocator protein and Single-minded) domain of the dimeric Escherichia coli aerotaxis receptor Aer monitors cellular respiration through a redox-sensitive flavin adenine dinucleotide (FAD) cofactor. Conformational shifts in the PAS domain instigated by the oxidized FAD (FAD)/FAD anionic semiquinone (FAD) redox couple traverse the HAMP (histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins, and phosphatases) and kinase control domains of the Aer dimer to regulate CheA kinase activity. The PAS domain of Aer is unstable and has not been previously purified.

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