The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain.

The function of the intrinsically disordered Unique domain of the Src family of tyrosine kinases (SFK), where the largest differences between family members are concentrated, remains poorly understood. Recent studies in c-Src have demonstrated that the Unique region forms transient interactions, described as an intramolecular fuzzy complex, with the SH3 domain and suggested that similar complexes could be formed by other SFKs. Src and Lyn are members of a distinct subfamily of SFKs.

Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains.

Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes.

Erosion and Sediment Transport Modelling in Shallow Waters: A Review on Approaches, Models and Applications.

The erosion and sediment transport processes in shallow waters, which are discussed in this paper, begin when water droplets hit the soil surface. The transport mechanism caused by the consequent rainfall-runoff process determines the amount of generated sediment that can be transferred downslope. Many significant studies and models are performed to investigate these processes, which differ in terms of their effecting factors, approaches, inputs and outputs, model structure and the manner that these processes represent.

Influence of Chronic Heat Acclimatization on Occupational Thermal Strain in Tropical Field Conditions.

Objective: To examine whether non-heat acclimatized (NHA) emergency responders endure greater physiological and perceptual strain than heat acclimatized (HA) counterparts in tropical field settings.

Methods: Eight HA and eight NHA men urban search and rescue personnel had physiological and perceptual responses compared during the initial 4 hours shift of a simulated disaster in tropical conditions (ambient temperature 34.0 °C, 48% relative humidity, wet bulb globe temperature [WBGT] 31.

Loss of 10p material in a child with human papillomavirus-positive disseminated bilateral retinoblastoma.

Retinoblastoma (RB) is a malignant childhood tumor that results from loss or inactivation of both alleles of the RB1 gene. Human papillomavirus (HPV) DNA sequences have been found in RB tissue, suggesting a role of the viral infection with RB. We here describe a child with disseminated bilateral RB without familial history, who displayed a loss of material from 10p.