Publications by authors named "Hector F Losada"
Published data on survival of T2 gallbladder carcinoma (GBC) from different countries show a wide range of 5-year survival rates from 30-> 70%. Recently, studies have demonstrated substantial variation between countries in terms of their approach to sampling gallbladders, and furthermore, that pathologists from different continents apply highly variable criteria in determining stage of invasion in this organ. These findings raised the question of whether these variations in pathologic evaluation could account for the vastly different survival rates of T2 GBC reported in the literature.
View Article and Find Full Text PDFBackground: Acute pancreatitis is an important complication of endoscopic retrograde cholangiography (ERC), occurring between 1-10% of patients. Several randomized controlled trials and meta-analyses have demonstrated the effectiveness of nonsteroidal anti-inflammatories (NSAIDs) such as diclofenac and indomethacin as a post-ERC pancreatitis (PEP) prophylaxis. The aim is to determine if the rectal diclofenac use reduces the PEP rate.
View Article and Find Full Text PDFArticle Synopsis
- The study examines differences in presentation and outcomes between patients with incidental gallbladder carcinoma (GBC) and those with suspected GBC, finding that over half of GBC cases are discovered incidentally.
- Out of 571 patients analyzed, 22.4% had preoperative suspicion of malignancy, while 77.6% were found incidentally; incidentally discovered tumors were generally smaller, better differentiated, and less likely to have metastasized.
- The median survival rate for incidentally discovered GBC was significantly better at 32.3 months compared to 5.8 months for suspected GBC, highlighting that preoperative suspicion is a significant risk factor for worse outcomes.