Effect of Digital-Tool-Supported Basal Insulin Titration Algorithm in Reaching Glycemic Control in Patients with Type 2 Diabetes in Mexico.

Background: My Dose Coach (MDC) is a mobile application combined with a web portal that can suggest optimized basal insulin (BI) injection doses using Self-Measured Plasma Glucose (SMPG) and hypoglycemia data. This study aimed to evaluate its efficacy on patients reaching SMPG and Fasting blood glucose (FBG) target range 90-130 mg/dl (5-7.2 mmol/L) goals without severe hypoglycemic episodes.

Underutilization of insulin and better metabolic control. A NOVA clinic experience.

Objective: To present the results of metabolic control in patients with type 2 Diabetes Mellitus from a private clinic in Northern Mexico.

Methods: This cross-sectional study used retrospective data obtained from electronic records from a private outpatient clinic at the end of 2018. Inclusion criteria were a diagnosis of T2DM and age ≥ 18 years.

[Adequate restitution in primary hypothyroidism depending on levothyroxine formulations].

Background: The prevalence of primary hypothyroidism (PH) is around 3.8%-4.6% in general population.

Neutral protamine hagedorn/regular insulin in the treatment of inpatient hyperglycemia: Comparison of 3 basal-bolus regimens.

Aim: To compare the safety and efficacy or 3 basal-bolus regimens of neutral protamine hagedorn (NPH)/regular insulin in the management of inpatient hyperglycemia.

Methods: We randomized 105 patients with blood glucose levels between 140 and 400 mg/dL to a basal-bolus regimen of NPH insulin given once ( = 30), twice ( = 40) or three times ( = 35) daily, in addition to pre-meal regular insulin. Major outcomes included were differences in glycemic control, frequency of hypoglycemia and total insulin dose.

SGLT2 inhibitors as add on therapy in type 2 diabetes: a real world study.

Background: Type 2 diabetes mellitus (T2DM) is a progressive chronic disease associated with severe microvascular and macrovascular complications. Our aim is to assess the real world effectiveness of SGT" inhibitors in achieving metabolic therapeutic goals.

Methods: A retrospective, observational study.

Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: A narrative review.

Steroids are drugs that have been used extensively in a variety of conditions. Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have several side effects, being hyperglycemia one of the most common and representative. In the present review, we discuss the main epidemiologic characteristics associated with steroid use, with emphasis on the identification of high risk populations.

Clinical course of diabetic ketoacidosis in hypertriglyceridemic pancreatitis.

Objectives: Hypertriglyceridemic pancreatitis (HP) is an uncommon condition accounting for 1% to 4% of cases of acute pancreatitis, mostly associated with poor glycemic control. Diabetic ketoacidosis (DKA) may complicate the clinical course of HP. Our objective was to identify clinical and demographic differences between HP and DKA patients compared with those without DKA.

[Efficacy and safety of initial treatment with glimpeiride versus sitagliptin in type 2 diabetes].

Background: Diabetes mellitus type 2 (DM2) is a multifactorial disease that can be treated with oral antiglycemic medication or with insulin. The antiglycemic drugs glimepiride and sitagliptin have different mechanisms of action, and have not been directly compared in a Latin-American population with recent DM2 diagnostic.

Methods: The primary objective in this randomized (1:1), multicentric, two arms, open study with adult patients, was to compare the efficacy of glimepiride with sitagliptin in a DM2 population naïve to treatment.

Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.

Acute pancreatitis and diabetic ketoacidosis are unusual adverse events following chemotherapy based on L-asparaginase and prednisone as support treatment for acute lymphoblastic leukemia. We present the case of a 16-year-old Hispanic male patient, in remission induction therapy for acute lymphoblastic leukemia on treatment with mitoxantrone, vincristine, prednisone, and L-asparaginase. He was hospitalized complaining of abdominal pain, nausea, and vomiting.

Hemoglobin A1c: a reliable and accurate test for diabetes care? A prospective study in Mexico.

Objective: To compare the concordance correlation coefficient for HbA1c results in an in-field experience.

Materials And Methods: A prospective study in Monterrey, Mexico from April to August 2012 was conducted to evaluate the day-to-day clinical situation when measuring HbA1c. Blood samples from 38 consecutive patients were sent to seven local laboratories and one international reference laboratory.

Association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in individuals 65 years or more with diabetes from a Geriatric Service in Monterrey, Mexico.

Background And Objective: Cognitive impairment and dementia are common geriatric syndromes in diabetic patients. Inflammation plays a crucial role in the pathophysiology of Alzheimer's disease and cognitive impairment. Cyclooxygenases (COX) 1 and 2 participate in inflammation.

Continuous glucose monitoring in acute coronary syndrome.

Background: Diabetes mellitus is an independent risk factor for cardiovascular disease.

Objective: To compare the efficacy of devices for continuous glucose monitoring and capillary glucose monitoring in hospitalized patients with acute coronary syndrome using the following parameters: time to achieve normoglycemia, period of time in normoglycemia, and episodes of hypoglycemia.

Methods: We performed a pilot, non-randomized, unblinded clinical trial that included 16 patients with acute coronary artery syndrome, a capillary or venous blood glucose ≥ 140 mg/dl, and treatment with a continuous infusion of fast acting human insulin.

[Clinical characteristics of the thyroid follicular carcinoma].

Background: the prevalence of thyroid follicular carcinoma (TFC) is 39 % in patients with an undetermined histological diagnosis. The aim was to know the prevalence of TFC in a hospital with high population concentration.

Methods: surgical reports with a final diagnosis of TFC were reviewed.

Hyperglycemia related to high-dose glucocorticoid use in noncritically ill patients.

Background: Glucocorticoids commonly cause drug-induced diabetes. This association is well recognized but available evidence does not answer clinically relevant issues in subjects without diabetes.

Methods: Thirty-five individuals without diabetes with a recent diagnosis of acute lymphoblastic leukemia or non-Hodgkin's lymphoma on high-dose glucocorticoid therapy were studied.

Galectin labeling of cells from paraffinized tissues may serve as a diagnostic tool in the detection and classification of thyroid carcinomas.

This study seeks to determine whether the relative levels of attachment to galectins 1 and 3 of cells from thyroid tissues embedded in paraffin blocks can differentiate thyroid tumors from normal tissues. A total of 48 thyroid paraffin sample blocks from 4 groups of patients were analyzed: 12 samples served as controls, 12 samples were from patients with thyroid adenoma, 12 samples were from patients with thyroid follicular carcinoma, and 12 samples were from patients with thyroid papillary carcinoma. The relative attachment of cells to galectins 1 and 3 antigens was determined using the InnoCyte™ ECM Cell Adhesion kit at different cell sample concentrations.

Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses.

Objective: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations.

[Prevalence of type 2 diabetes mellitus in elderly patients and associated factors in a general hospital of the north of Mexico].

Unlabelled: There are few reports on the impact of diabetes in the geriatric population.

Objective: To determine the prevalence of diabetes in the geriatric population in a hospital in Northeast Mexico.

Design: A cross-sectional study and a probabilistic sampling were made.

The rate of primary hypothyroidism in diabetic patients is greater than in the non-diabetic population. An observational study.

Background And Objective: The aim of our study was to identify the rate of diabetic patients treated for hypothyroidism and compare them with a group without type 2 diabetes mellitus (T2DM).

Patients And Methods: We reviewed the computerized clinical records of 5161 patients. We identified diabetic patients treated with l-thyroxine.

[Recombinant human TSH in pediatric thyroid cancer].

The treatment of pediatric thyroid cancer usually includes thyroid surgery, therapeutic radioactive iodine ablation, and TSH suppression with levotiroxine. Thyroid hormone withdrawal in the usual follow-up of thyroid cancer has adverse effects on patients. Recominant human (Rh) TSH has the advantage of avoiding both hypothyroidism, with a major impact on the patient's quality of life, and the side effects on tumor growth related to the long-lasting TSH increase.

[Thyroid incidentaloma frequency in a university hospital].

Background: The prevalence of thyroid incidentaloma is variable and always created the dilemma of how to manage them. The objective was to determine the frequency of thyroid incidentalomas in a University Hospital.

Methods: A descriptive, transversal, prospective study was done; a non-probabilistic sample was used with patients who met the following criteria: >18 years, indiscriminate sex, and an image that included neck: ultrasound, computed tomography and/or magnetic resonance.

[Frailty and its association with mortality, hospitalization and functional dependence in Mexicans aged 60-years or older].

Fundamento Y Objetivo: Determinar la asociación entre fragilidad y mortalidad, dependencia funcional, caídas y hospitalizaciones en el Estudio Nacional de Salud y Envejecimiento en México (ENASEM).

Sujetos Y MÉtodos: Estudio prospectivo poblacional en México en el que se seleccionaron sujetos de 60 años o más, que fueron evaluados en las variables de fragilidad durante la primera vuelta del estudio en el año 2001 y que incluyó: dificultad para levantarse de una silla después de haber estado sentado(a) durante largo tiempo, pérdida de peso de 5 kilogramos o más en los últimos dos años y falta de energía. Los sujetos fueron catalogados como robustos, prefrágiles y frágiles cuando tenían cero, una o dos de las características anteriores, respectivamente.