Publications by authors named "Hector Carreno Gutierrez"
Article Synopsis
- - Model fish species like sticklebacks and zebrafish are used for DNA sampling, typically through fin clipping, which can harm the fish.
- - An alternative method, skin swabbing, is less invasive than fin clipping and shows reduced cortisol levels and behavioral changes immediately after the procedure.
- - While swabbing leads to less immediate stress and variability in results, it may cause delayed behavioral changes, making it a more refined option to enhance fish health and welfare during DNA collection.
Article Synopsis
- - The study investigates the role of the histamine H3 receptor (Hrh3) in aggression behavior using a zebrafish model, revealing its significant impact on aggression and anxiety levels.
- - Researchers created a Hrh3 null mutant line using CRISPR and analyzed changes in behavior and neural activity through imaging techniques, finding that inactivation of Hrh3 leads to reduced aggression and increased anxiety.
- - The findings suggest that Hrh3 signaling is crucial for aggression and anxiety regulation, indicating potential therapeutic targets for addressing similar human conditions characterized by heightened aggression.
Screening for drugs to reduce zebrafish aggression identifies caffeine and sildenafil.
Eur Neuropsychopharmacol
January 2020
Article Synopsis
- Aggression is a symptom of psychiatric disorders, but current treatment drugs are non-specific and may cause side effects.
- Researchers tested 94 drugs and found that caffeine and sildenafil specifically reduce aggression in zebrafish, with distinct effects on attention and impulsivity.
- The study indicates that juvenile zebrafish can be a useful model for screening drugs that target aggression and offers insights into the neural mechanisms involved.
The three-spined stickleback (Gasterosteus aculeatus) is a small teleost fish that is ubiquitous across the Northern Hemisphere. Among the behaviours that have been characterised in this species is ritualized courtship, aggressiveness and parental behaviour. Whereas three-spined sticklebacks have been used for ecological, evolutionary, parasitological and toxicological research, its complex behavioural repertoire and experimental advantages have not been exploited for basic neuroscience research.
View Article and Find Full Text PDFThe formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types.
View Article and Find Full Text PDFArticle Synopsis
- Scientists found that a special type of tiny RNA called miRNA can control other RNA messages in the body, but some strong connections can cause the miRNA to get destroyed instead.
- They studied how this works in zebrafish and mice, discovering that a specific RNA can change how these animals behave.
- When they changed the part of the RNA that connects with miRNA in mice, it messed up their movement and learning because the miRNA couldn't do its job properly.
Background: Although aggression is a common symptom of psychiatric disorders the drugs available to treat it are non-specific and can have unwanted side effects. The zebrafish is an ideal model for aggression research. Zebrafish are small, amenable to genetic and pharmacological manipulation, and agonistic behaviour can be measured reliably.
View Article and Find Full Text PDFNitric oxide (NO) is a gaseous neurotransmitter that has important behavioural functions in the vertebrate brain. In this study we compare the impact of decreased nitric NO signalling upon behaviour and neurobiology using both zebrafish and mouse. nitric oxide synthase mutant (nos1) zebrafish show significantly reduced aggression and an increase in anxiety-like behaviour without altered production of the stress hormone cortisol.
View Article and Find Full Text PDFAggression in non-human vertebrates: Genetic mechanisms and molecular pathways.
Am J Med Genet B Neuropsychiatr Genet
July 2016
Aggression is an adaptive behavioral trait that is important for the establishment of social hierarchies and competition for mating partners, food, and territories. While a certain level of aggression can be beneficial for the survival of an individual or species, abnormal aggression levels can be detrimental. Abnormal aggression is commonly found in human patients with psychiatric disorders.
View Article and Find Full Text PDFRisperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein binding (>90%). Since new strategies to improve efficient treatments are needed, we studied the efficiency of anionic G4.
View Article and Find Full Text PDF