Publications by authors named "Hector Alejandro de-la-Cruz Cruz"
Exploring alternative anthelmintic compounds: Impact of peruvin, hentriacontane/1-nonacosanol and their synergistic effect on the health of Meriones unguiculatus infected with Haemonchus contortus.
Vet Parasitol
December 2024
Article Synopsis
- * In this study, plant-derived compounds peruvin and hentriacontane/1-nonacosanol were evaluated for their potential to control the parasite, showing promising results in laboratory tests with 100% larvicidal reduction in their combined form.
- * However, while effective, both compounds exhibited some health risks in test subjects, highlighting the need for further research to balance efficacy with safety and to determine optimal dosages.
Article Synopsis
- A blood-feeding parasite affecting grazing sheep leads to significant economic losses, prompting the need for alternative treatments due to drug resistance.
- The study focuses on the ethyl acetate extract of a specific plant in the Asteraceae family, identifying its anthelmintic properties and exploring the pharmacodynamic interactions of its bioactive compounds.
- Four compounds (1-nonacosanol, hentriacontane, peruvin, and cinic acid) were isolated, with binary mixtures showing increased lethality against infective larvae, indicating potential synergistic effects among the compounds.
Article Synopsis
- - Haemonchus contortus is a harmful parasite in sheep that causes economic losses, leading to the need for alternative treatments since it has become resistant to traditional anthelmintics.
- - The study focuses on extracts from the plant Artemisia cina, which show significant anthelmintic effects, particularly the n-hexane extract, while a new compound named cinic acid was identified from the ethyl acetate extract.
- - Cinic acid has shown remarkable larvicidal activity against H. contortus, being 256 times more potent than the ethyl acetate extract at its effective concentration (LC50) and significantly enhancing the search for natural antiparasitic solutions.
Biochemical parameters, oxidative stress biomarkers, and anatomopathological changes in Wistar rats treated with 3'-demethoxy-6-O-demethylisoguaiacin and norisoguaiacin.
Sci Rep
May 2024
Artemisia cina (Ac) is a plant with anthelmintic compounds such as 3'-demethoxy-6-O-demethylisoguaiacin (D) and norisoguaiacin (N). Three major objectives were proposed: (1) To evaluate biochemical parameters in blood (2) to determine the tissue oxidative stress by biomarkers as TBARS and glutathione peroxidase activity, and (3) to evaluate anatomopathological changes in organs such as the brain, liver, kidney, and lung after oral administration of n-hexane extract of Ac and D and N. D and N were administrated following the OECD guides for acute oral toxicity evaluation (Guide 420).
View Article and Find Full Text PDFis a plant used in traditional Chinese medicine as a remedy for parasitic diseases. This study describes the isolation and chemical characterization of anthelmintic compounds of against infective larvae (L) through lethal testing. Previously, three extracts--hexane (HexAc), ethyl acetate (EtOAc) and methanol (MeOAc)-were evaluated at concentrations of 4 to 0.
View Article and Find Full Text PDFAn Artemisia cina n-hexane extract reduces the Haemonchus contortus and Teladorsagia circumcincta fecal egg count in naturally infected periparturient goats.
Trop Anim Health Prod
February 2022
The objective of this study was to evaluate an n-hexane extract of Artemisia cina (Acn-h) as a natural anthelmintic treatment for periparturient goats naturally infected with the nematodes Haemonchus contortus and Teladorsagia circumcincta. A total of 200 periparturient Alpine and Nubian goats were used. Deworming criteria were based on the following parameters: fecal egg account (epg), ocular mucosa color (OMC), and body condition (BC).
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