The lack of predictors for rapid progression in prostate cancer patients receiving sipuleucel-T.

Sipuleucel-T is an immunotherapy indicated for the treatment of metastatic prostate cancer. It offers a new mechanism to treat prostate cancer without the side effects of hormone therapies and chemotherapies. In previous studies sipuleucel-T did not delay disease progression, but demonstrated an overall survival benefit compared to placebo.

The predicted influence of climate change on lesser prairie-chicken reproductive parameters.

The Southern High Plains is anticipated to experience significant changes in temperature and precipitation due to climate change. These changes may influence the lesser prairie-chicken (Tympanuchus pallidicinctus) in positive or negative ways. We assessed the potential changes in clutch size, incubation start date, and nest survival for lesser prairie-chickens for the years 2050 and 2080 based on modeled predictions of climate change and reproductive data for lesser prairie-chickens from 2001-2011 on the Southern High Plains of Texas and New Mexico.

Changes to medication-use processes after overdose of U-500 regular insulin.

Purpose: Modifications made to medication-use processes after an overdose of U-500 regular insulin are described.

Summary: After a medication error occurred with U-500 regular insulin, a multidisciplinary team of physicians, nurses, advanced-practice nurses, and pharmacists was created to review and improve the ordering, dispensing, and administration processes associated with U-500 regular insulin. The group determined that current safety practices for managing insulin were inadequate.

Early GABA(A) receptor clustering during the development of the rostral nucleus of the solitary tract.

While there is an abundance of gamma-aminobutyric acid (GABA) in the gustatory zone of the nucleus of the solitary tract of the perinatal rat, we know that GABAergic synapse formation is not complete until well after birth. Our recent results have shown that GABA(B) receptors are present at birth in the cells of the nucleus; however, they do not redistribute and cluster at synaptic sites until after PND10. The present study examined the time course of appearance and redistribution of GABA(A) receptors in the nucleus.

Subcellular localization of GABA receptors in the central nervous system using post-embedding immunohistochemistry.

The following detailed protocol can be applied to demonstrate the localization of GABA receptors in CNS neurons at the ultrastructural level. While others have investigated receptors at the electron microscopic level using immunocytochemical techniques, the appearance of the tissue is usually poor and analyses of the distribution of receptors is limited. The methodology described in this paper allows for optimal preservation of the tissue while retaining immunogenicity.

Redistribution and increased specificity of GABA(B) receptors during development of the rostral nucleus of the solitary tract.

Recent results show that there is an abundance of gamma-aminobutyric acid (GABA) before GABAergic synapses have formed in the gustatory zone of the nucleus of the solitary tract. These results suggest that a non-synaptic, developmental function may exist for GABA prior to synaptogenesis. However, GABA exerts its physiological effect via its receptors, the development of which is a largely unknown process.

An air quality data analysis system for interrelating effects, standards, and needed source reductions: Part 12. Effects on man, animals, and plants as a function of air pollutant impact.

The impact-effect mathematical model, developed in 1991, improves on a previous mathematical model, and was developed to predict biological response as a function of air pollutant impact. Impact is defined here as exposure duration multiplied by air pollutant concentration raised to an exponent (t.cd).

Model analysis of interactive effects of ozone and water stress on the yield of soybean.

The interactive effects of ozone and water stress on the yield of soybean (Glycine max (L.) Merr. 'Davis') were addressed with a growth model of soybean.

Fibromyalgia syndrome. New associations.

Previous research has demonstrated a number of conditions, such as sleep disturbance, fatigue, depression, spastic colon and mitral valve prolapse, associated with fibromyalgia. The present report describes additional symptoms and medical conditions that appear to be associated with the syndrome based on a survey of 554 individuals with fibromyalgia compared with a group of 169 controls. Individuals with fibromyalgia self report a greater incidence of bursitis, chondromalacia, constipation, diarrhea, temporomandibular joint dysfunction, vertigo, sinus and thyroid problems.

Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits.

Glucarate is normally present in tissues and body fluids and is in equilibrium with D-glucaro-1,4-lactone, a natural inhibitor of beta-glucuronidase activity. Dietary calcium glucarate, a sustained-release from of glucarate, elevates the blood level of D-glucaro-1,4-lactone which suppresses blood and tissue beta-glucuronidase activity. A single dose of CaG (4.

Modeling the effects of ozone on soybean growth and yield.

A simple mechanistic model was developed based on an existing growth model in order to address the mechanisms of the effects of ozone on growth and yield of soybean [Glycine max. (L.) Merr.

Effects of ozone on three open-pollinated families of Pinus taeda L. grown in two substrates.

Seedlings from three open-pollinated loblolly pine (Pinus taeda L.) families grown in a mixture of commercial peat moss and grade 3 vermiculite (1:3 by volume) or a mixture of mineral soil and peat (1:1 by volume) were exposed to 0, 160 or 320 ppb ozone (O3) for 6h/day, 4 days/week for 8 weeks beginning 12 weeks after transplanting. Before exposures began, seedlings grown in the vermiculite-peat substrate were taller but smaller in diameter than those grown in the mineral soil-peat substrate.

Effects of air quality on foliar injury, growth, yield, and quality of muskmelon.

An evaluation of the effects of ambient ozone (O3) on muskmelon was conducted with the use of open-top chambers (OTCs). 'Superstar' muskmelons grown in charcoal-filtered (CF) chambers compared to those grown in nonfiltered (NF) chambers showed significant differences in the severity of visible foliar O3 injury. Furthermore, plants grown in NF conditions had significantly less (21.