RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.

Background: As a small G protein of Ras family, Ras-like-without-CAAX-1 (RIT1) plays a critical role in various tumors. Our previous study has demonstrated the involvement of RIT1 in promoting malignant progression of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear.

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most lethal malignant cancers across the world. It has a poor prognosis and lacks effective therapies, especially for patients with advanced-stage cancer, indicating an urgent need for new therapies and novel therapeutic targets. Here, by screening the U.

Surface Reconstruction of CsPbBr Nanocrystals by the Ligand Engineering Approach for Achieving High Quantum Yield and Improved Stability.

Oleylamine/oleic acid (OAm/OA) as the commonly used ligand is indispensable in the synthesis of perovskite nanocrystals (PNCs). Unfortunately, poor colloidal stability and unsatisfactory photoluminescence quantum yield (PLQY) are observed, resulting from a highly dynamic binding nature between ligands. Herein, we adopt a facile hybrid ligand (DDAB/ZnBr) passivation strategy to reconstruct the surface chemistry of CsPbBr NCs.

Self-assembly formation of CuI hybrid micron phosphors with tunable emission for multifunctional applications.

Low-cost and eco-friendly CuI hybrid compounds with various structures have recently attracted increasing attention due to their excellent optical properties and promising phosphor applications. However, the poor solubility and solution processability of bulk powders with agglomerated particle limited their practical applications greatly. In this work, we reported the self-assembly formation of CuI hybrid micron phosphors via the aqueous PVP micelle-assisted assembly route.

In Situ Formed Core-Shell LiZnMnO@ZnMnO as Cathode for Li-Ion Batteries.

Elemental doping and surface modification are commonly used strategies for improving the electrochemical performance of LiMnO, such as the rated capacity and cycling stability. In this study, in situ formed core-shell LiZnMnO@ZnMnO cathodes are prepared by tuning the Zn-doping content. Through comprehensive microstructural analyses by the spherical aberration-corrected scanning transmission microscopy (Cs-STEM) technique, we shed light on the correlation between the microstructural configuration and the electrochemical performance of Zn-doped LiMnO.

Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a highly malignant tumor and its progression is associated with altered lipid metabolism in precancerous lesions, such as non-alcoholic fatty liver disease. Here, we identified sperm associated antigen 4 (SPAG4), and explored its oncogenic role in HCC progression. Database analysis and immunohistochemistry indicated increased level of SPAG4 in HCC tissues which was of prognostic value.

Thermoinduced structural-transformation and luminescent conversion in hybrid manganese halides.

We report here the synthesis of hybrid manganese halide crystals, (CHN)MnCl· HO and (CHN)MnCl, by using the same organic ligand 2-methylimidazole. Upon heating treatment, the red-emissive (CHN)MnCl· HO crystal is structurally transformed into green-emissive (CHN)MnClcrystal. The crystal structural analysis reveals that the [MnCl· HO]octahedra chains decompose into mono [MnCl]tetrahedra, accompanied by the departure of HO molecules.

High-efficiency synthesis of Cu superfine particles via reducing cuprous and cupric oxides with monoethanolamine and their antimicrobial potentials.

Cuprous oxide (CuO) and cupric oxide (CuO) are widely available and low cost raw materials. Their applications as precursors for wet chemical synthesis of metallic Cu materials are greatly limited due to their insoluble in water and most organic solvents. In this work, copper superfine particles (Cu SPs) are synthesized using CuO and CuO as precursors via a heating process in monoethanoamine (MEA).

Understanding the Effect of Al Doping on the Electrochemical Performance Improvement of the LiMnO Cathode Material.

It is well known that the electrochemical performance of spinel LiMnO can be improved by Al doping. Herein, combining X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, and spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM) with electron-beam (E-beam) irradiation techniques, the influence of Al doping on the structural evolution and stability improvement of the LiMnO cathode material is revealed. It is revealed that an appropriate concentration of Al ions could dope into the spinel structure to form a more stable LiAlMnO phase framework, which can effectively stabilize the surface and bulk structure by inhibiting the dissolution of Mn ions during cycling.

CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway.

Pancreatic cancer is one of the most aggressive tumors with poor prognosis and new targetable therapies are urgently required. CSE1L (chromosome segregation 1 like) is thought to play an important role in tumorigenesis and acts as a cancer therapeutic target. However, the biological function and the underlying mechanism of CSE1L in pancreatic cancer are still not fully explicit.

Atomic Insights into Ti Doping on the Stability Enhancement of Truncated Octahedron LiMnO Nanoparticles.

Ti-doped truncated octahedron LiTiMnO nanocomposites were synthesized through a facile hydrothermal treatment and calcination process. By using spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM), the effects of Ti-doping on the structure evolution and stability enhancement of LiMnO are revealed. It is found that truncated octahedrons are easily formed in Ti doping LiMnO material.

A new risk model comprising genes highly correlated with CD133 identifies different tumor-immune microenvironment subtypes impacting prognosis in hepatocellular carcinoma.

The existence of cancer stem cells (CSCs), marked by CD133, is the primary cause of death in hepatocellular carcinoma (HCC). Here, we generated a new risk model comprising the signatures of four genes highly correlated with CD133 (CD133) that help improve survival in HCC. Three datasets were used to identify the differential CD133 genes by comparing sorted CD133 liver CSCs and CD133 differentiated counterparts.

Synergistic effect of cobalt boride nanoparticles on MoS nanoflowers for a highly efficient hydrogen evolution reaction in alkaline media.

The development of efficient, stable and low-cost electrocatalysts for the alkaline hydrogen evolution reaction (HER) is critical for large-scale, economically viable water splitting. In this work, we successfully prepared non-precious metal CoB@MoS2 hybrid electrocatalysts for the HER in alkaline media by the reductive growth of cobalt boride nanoparticles (CoB NPs) on the surface of MoS2 nanoflowers (MoS2 NFs). The CoB@MoS2-0.

TBX2 Identified as a Potential Predictor of Bone Metastasis in Lung Adenocarcinoma via Integrated Bioinformatics Analyses and Verification of Functional Assay.

Bone metastasis from patients with advanced lung adenocarcinoma (LAC) is a very serious complication. To better understand the molecular mechanism, our current study sheds light on identification of hub genes mediating bone metastatic spread by combining bioinformatic analysis with functional verification. First, we downloaded a lung adenocarcinoma dataset (GSE76194) from Gene Expression Omnibus, analyzed differentially expressed genes (DEGs) through Limma package in R software and constructed a protein-protein interaction network.

RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.

Background: KH-type splicing regulatory protein (KHSRP) plays an important role in cancer invasion, but the relevant mechanism is not well known. In the present study, we investigated the function and potential molecular mechanism of KHSRP in non-small cell lung cancer (NSCLC) metastasis and elucidated its clinical significance.

Methods: Isobaric tags for relative and absolute quantitation and the SWATH™ approach were combined with nanoliquid chromatography-tandem mass spectrometry analysis to identify metastasis-associated nucleoproteins in NSCLC.

Facile Synthesis of 3d Transition-Metal-Doped α-Co(OH) Nanomaterials in Water-Methanol Mediated with Ammonia for Oxygen Evolution Reaction.

Layered cobalt hydroxides are cost-efficient electrocatalysts for oxygen evolution reaction (OER) in the field of energy conversion. Herein, we developed a facile synthesis method of 3d transition-metal-doped α-Co(OH) nanomaterials mediated with ammonia in water-methanol at room temperature. The doping of Cu and Ni leads to flower-like nanostructures similar to pure α-Co(OH), whereas the doping of Fe produces nanoparticles with more than 2 times larger surface area in comparison with the Cu- and Ni-doped nanoflowers.

DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.

E3 ubiquitin ligases, which are key enzymes in the ubiquitin proteasome system, catalyze the ubiquitination of proteins to target them for proteasomal degradation. Emerging evidence suggests that E3 ubiquitin ligases play important roles in the development and progression of lung cancer. In our study, we characterized the gene expression landscape of lung cancer using data obtained from TCGA to explore the changes in E3 ubiquitin ligase containing the regulators of E3 ubiquitin ligase activity.

CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation.

Approximately 90% of patients diagnosed with non-small cell lung cancer (NSCLC) die due to distant metastases. However, the complicated molecular and cellular mechanisms involved in lung cancer metastasis remain poorly understood. Copine III (CPNE3), a member of a Ca-dependent phospholipid-binding protein family, was identified as a novel metastasis-associated protein in NSCLC in our previous study, however, its function in metastasis remains unclear.

Luminescent Nanofluids of Organometal Halide Perovskite Nanocrystals in Silicone Oils with Ultrastability.

Luminescent nanofluids are successfully prepared by directly dispersing organometal halide perovskite nanocrystals (OHP NCs) with different emission colors in silicone oils. The photoluminescence quantum yields of nanofluids with green, blue and red emission are 47, 32, and 19%, respectively. Furthermore, the nanofluids greatly enhance the stability of OHP NCs and show excellent resistance against moisture, heat and ultraviolet light.

Formation and dispersion of organometal halide perovskite nanocrystals in various solvents.

The solvent-induced precipitation in a mixture of good and poor solvents was often used to synthesize organometal halide perovskite nanocrystals (OMHP NCs). Here we investigate the formation of OMHP NCs by using HBr based precursors in various solvents. Various emission colors and morphologies of perovskite NCs were obtained depending on the solvents used.

Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.

MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression and protein synthesis. Our previous study demonstrated that miR-148a suppressed the metastasis of non-small cell lung cancer (NSCLC) and . However, the modulatory mechanism of this effect remains unclear.

MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.

Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis of non-small cell lung cancer (NSCLC). In particular, elevated expression of LINC00963 (MetaLnc9) in human NSCLC specimens correlated with poor prognosis, promoted migration and invasion of NSCLC cells , and enhanced lung metastasis formation Mechanistic investigations showed that MetaLnc9 interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in NSCLC cells, leading to activation of the oncogenic AKT/mTOR signaling pathway.

(Diisopropylammonium)MnBr: a multifunctional ferroelectric with efficient green-emission and excellent gas sensing properties.

Combination of excellent optical properties and ferroelectricity of hybrid materials leads to high-performance optoelectronic devices. Here we present a new organic-inorganic hybrid compound (diisopropylammonium)MnBr (DIPAMnBr) which shows high temperature ferroelectricity accompanied by highly efficient green-light emission. DIPAMnBr also exhibits sensitive and selective optical response to alcohol vapors.

CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival.

To discover tumor-associated proteins in osteosarcoma, a quantitative proteomic analysis was performed to identify proteins that were differentially expressed between osteosarcoma and human osteoblastic cells. Through clinical screening and a functional evaluation, chromosome segregation 1-like (CSE1L) protein was found to be related to the growth of osteosarcoma cells. To date, little is known about the function and underlying mechanism of CSE1L in osteosarcoma.