We devise reduced-dimension metrics for effectively measuring the distance between two points (i.e., microstructures) in the microstructure space and quantifying the pathway associated with microstructural evolution, based on a recently introduced set of hierarchical n-point polytope functions P_{n}.
View Article and Find Full Text PDFTo evaluate the sludge reduction of three metabolic uncouplers (3,3',4',5-tetrachlorosalicylanilide (TCS), 2,4-dichlorophenol (DCP), and tetrakis (hydroxymethyl) phosphonium sulfate (THPS)), we conducted continuous experiments on laboratory-scale anaerobic-anoxic-oxic processes. The three metabolic uncouplers were separately added in each oxic tank of the three systems, and a system without uncoupler addition was used as control. During the 85-day operation, sludge production and observed growth yields decreased to 38.
View Article and Find Full Text PDFAn accurate knowledge of the complex microstructure of a heterogeneous material is crucial for its performance prediction, prognosis and optimization. X-ray tomography has provided a nondestructive means for microstructure characterization in 3D and 4D (i.e.
View Article and Find Full Text PDFPhys Rev E Stat Nonlin Soft Matter Phys
August 2015
Reconstructing heterogeneous materials from limited structural information has been a topic that attracts extensive research efforts and still poses many challenges. The Yeong-Torquato procedure is one of the most popular reconstruction techniques, in which the material reconstruction problem based on a set of spatial correlation functions is formulated as a constrained energy minimization (optimization) problem and solved using simulated annealing [Yeong and Torquato, Phys. Rev.
View Article and Find Full Text PDFAims/hypothesis: The aim of this study was to investigate whether genetic variance can influence the efficacy of glibenclamide in patients with type 2 diabetes.
Methods: A total of 747 patients with type 2 diabetes was enrolled from the Xiaoke Pills Clinical Trial, which is a double-blind, randomised controlled trial. All the patients had been treated with glibenclamide for 48 weeks, with strict drug dose adjustment and data collection.
Objectives: Early, efficient, and accurate evaluation for organ failure is an important step for improving outcome in severe acute pancreatitis (SAP). We aim to develop a method that can early, efficiently, and accurately evaluate the in-hospital organ failure in patients with SAP.
Methods: Using multivariate logistic regression analysis, the associative factors for in-hospital organ failure were evaluated retrospectively from conventional data obtained from 393 patients with SAP from 2000 to 2012.
Background: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of major depression. Individuals with type 2 diabetes (T2DM) have a high prevalence of major depression and low levels of BDNF. We therefore explored whether the BDNF Val66Met polymorphism is associated with co-morbid depression and whether depression affects the serum levels of BDNF in a Han Chinese subjects with T2DM.
View Article and Find Full Text PDFObjective: To investigate the effects of atorvastatin on bone formation, bone resorption and bone mineral density in Wistar rats.
Methods: Sixty healthy male Wistar rats were randomly divided into one control group treated with vehicle alone and three drug treatment groups, which were treated with atorvastatin at 5 mg/kg x d, 25 mg/kg x d and 50 mg/kg x d respectively. Left femur BMD and bone metabolic parameters were measured after 8 weeks of treatment.
J Gastroenterol Hepatol
August 2010
Background And Aims: The aim of this study is to analyze factors (especially serum total cholesterol) that can enable early prediction of in-hospital mortality of patients with severe acute pancreatitis (SAP).
Methods: Predictive factors (especially serum total cholesterol) for in-hospital mortality were evaluated retrospectively from the clinical data obtained from 338 SAP patients in our hospital from January 1999 to January 2008, who underwent intensive care, blood routine, blood biochemical tests and even computed tomography at the time of admission.
Results: This analysis revealed that within 24 h after admission, serum total cholesterol (TC) was a mortality-reduced factor when it is between 4.