A novel micropeptide miPEP205 suppresses the growth and metastasis of TNBC.

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and poses a treatment challenge due to high recurrence risk. Consequently, there is an urgent need for novel and efficacious therapies targeting TNBC. In this context, our study delineates the identification and characterization of a long non-coding RNA (lncRNA)-derived micropeptide miPEP205.

Li-Si alloy pre-lithiated silicon suboxide anode constructing a stable multiphase lithium silicate layer promoting Ion-transfer kinetics.

Enhancing the initial Coulombic efficiency (ICE) and cycling stability of silicon suboxide (SiO) anode is crucial for promoting its commercialization and practical implementation. Herein, we propose an economical and effective method for constructing pre-lithiated core-shell SiO anodes with high ICE and stable interface during cycling. The lithium silicon alloy (LiSi) is used to react with SiO in advance, allowing for improved ICE of SiO without compromising its reversible specific capacity.

A study of the relationship between brachial artery vasodilation and platelet/lymphocyte ratio in diabetic patients with coronary atherosclerosis.

Background: To investigate the correlation between brachial artery flow-mediated endothelium-dependent dilation (FMD) and platelet-lymphocyte ratio (PLR) in peripheral blood and coronary atherosclerosis in diabetic patients.

Methods: Seventy-five diabetic patients aged 62 ± 9 years, 68% male and 32% female, who underwent brachial artery endothelial function test and coronary CT scan were collected. Coronary artery calcification (CAC) was observed to assess the presence of coronary atherosclerosis, and high-resolution extravascular ultrasound was used to detect FMD.

Assessment of right ventricular structure and systolic function in amateur marathon runners using three-dimensional speckle tracking echocardiography.

Prolonged high-intensity endurance exercise has been reported to have adverse effects on the heart, which are further correlated with exercise dose. However, its effect on the right ventricle (RV) of amateur runners is unknown. This study aimed was to evaluate the early right ventricular structure and systolic function of amateur marathon runners by three-dimensional speckle tracking echocardiography (3D-STE), and to further analyze the correlation between relevant parameters and the amount of training.

Evaluation of left ventricular systolic function in patients with systemic lupus erythematosus using ultrasonic layer-specific strain technology and its association with cardiovascular events: a long-term follow-up study.

Background: Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease with potential cardiovascular involvement. Layer-specific strain (LSS) analysis is a new method that allows early detection of subtle left ventricular (LV) systolic dysfunction. The aim of this study was to evaluate LV systolic function in patients with SLE using conventional echocardiographic measurements and longitudinal strain (LS) and circumferential strain (CS) by LSS.

Delivery of astragalus polysaccharide by ultrasound microbubbles attenuate doxorubicin-induced cardiomyopathy in rodent animals.

The aim of this study was to investigate the cardioprotective effects and probable mechanism of ultrasound-targeted microbubble destruction (UTMD) combined with astragalus polysaccharide (APS) on diabetic cardiomyopathy (DCM) model rats. The DCM rats with diabetes and cardiomyopathy were induced via chronic treatment of doxorubicin and then randomly divided into the (1) DCM model group; (2) APS microbubble group; (3) UTMDgroup; and (4) APS microbubbles combined with UTMD group. After 4-week intervention, the fasting blood glucose levels, body weight, %HbA1c level and glucose tolerance of DCM rats received combination therapy were significantly improved as compared with those of UTMD or saline-treated ones.

Protective effect of glucagon-like peptide-1 mediated by ultrasound microbubbles on myocardial injury in rats with diabetic cardiomyopathy.

Ultrasound-targeted microbubble destruction, UTMD; glucagon-like peptide-1 receptor, GLP-1R; diabetic cardiomyopathy, DCM; Goto-Kakizaki, GK; velocity vector imaging, VVI; left ventricular end-diastolic diameter LVIDd; left ventricular end-systolic diameter, LvIDs; left ventricular end-diastolic pressure, LVEDP; fractional shortening, LVFs; left ventricular ejection fraction, LVEF; mean peak radial velocity, Vs; radial strain, Sr; radial strain rate, SRr; superoxide dismutase, SOD; malondialdehyde, MDA; glutathione peroxidase, GSH-Px; peroxisome proliferator-activated receptor-γ, PPAR-γ; nuclear transcription factor κB, NF-κB; insulin resistance, IR; total cholesterol, TC; total triglycerides, TG; creatine kinase, CK; lactate dehydrogenase, LDH; cardiac troponin I, cTnI; collagen volume fraction, CVF; Hematoxylin eosin, H&E.

Stabilization of heavy metals in MSWI fly ash with a novel dithiocarboxylate-functionalized polyaminoamide dendrimer.

A novel heavy metal chelating agent, dithiocarboxylate-functionalized polyaminoamide dendrimer (PAMAM-0G-DTC), was evaluated for the stabilization of heavy metals from municipal solids waste incineration (MSWI) fly ash. PAMAM-0G-DTC achieved overall stabilization performance at a lower dosage (3% w/w) and a wider pH range (2-13) compared to conventional chelating agents such as sodium dimethyl dithiocarbamate (SDD) and dithiocarboxylate-functionalized tetraethylenepentamine (TEPA-DTC). The leaching toxicity of Pb and Cd in the MSWI fly ash by PAMAM-0G-DTC stabilization met the landfill requirements but could not be achieved by SDD and TEPA-DTC even at a 10 wt% concentration.

Collision induced magnetic resonance in Cesium atoms.

The radiofrequency-optical double magnetic resonance in cesium atoms filled in a vapor cell is investigated experimentally. One resonant signal involving spin-exchange collisions is observed in the M type magnetic resonance spectrum. We solve Liouville equations describing the dynamics of the system and analyze the role of the spin-exchange collisions in the atomic population distributions under resonant conditions.