[Pharmacokinetic investigations of the transfer of antibiotics into amniotic fluid. Part III: Oxacillin (author's transl)].

After intravenous administration of 2 g of Oxacillin to 12 gravidae at the end of their pregnancy short-interval tests were made of the Oxacillin levels in the mothers' serum and -- intra-amnionic catheter in position -- in the amniotic fluid. The following pharmaco-kinetic data were determined: fictitious initial Oxacillin level (79 mcg/ml), elimination constant (1,044 h-1), half-value of elimination (39,88 min), fictitious distribution volume (25,31), distribution coefficient (0,3617 ml/g), total clearance (26,431 l/h) and invasion constant (0,0084 h-1). All given data were statistically confirmed.