ACE gene insertion/deletion polymorphism seminal associations in infertile men.

Purpose: We assessed seminal associations of the ACE gene insertion/deletion polymorphism in infertile men.

Materials And Methods: A total of 405 men were investigated, divided into healthy fertile men, and those with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia, respectively. They underwent semen analysis, and assessment of sperm acrosin activity, hypo-osmotic swelling, seminal 8-iso-prostaglandin-F(2α), total antioxidant capacity, α-glucosidase and ACE gene polymorphisms.