Biosynthesis of Iron Oxide Nanoparticles by Marine sp. SMGL39 with Antibiofilm Activity: In Vitro and In Silico Study.

One of the major global health threats in the present era is antibiotic resistance. Biosynthesized iron oxide nanoparticles (FeNPs) can combat microbial infections and can be synthesized without harmful chemicals. In the present investigation, 16S rRNA gene sequencing was used to discover sp.

Biological Applications, In Vitro Cytotoxicity, Cellular Uptake, and Apoptotic Pathway Studies Induced by Ternary Cu (II) Complexes Involving Triflupromazine with Biorelevant Ligands.

The novel mixed-ligand complexes derived from the parent antidepressant phenothiazine drug triflupromazine (TFP) were synthesized along with the secondary ligands glycine and histidine. [Cu(TFP)(Gly)Cl]·2HO (1) and [Cu(TFP)(His)Cl]·2HO (2) were examined for their in vitro biological properties. Cyclic voltammetry was used to study the binding of both complexes to CT-DNA.

Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR-2 Inhibitors and Endowed with Apoptotic Potential.

In this work, the cytotoxicity of monoclonal antibody (Cetuximab, Ce) and Fenbendazole (Fen), as well as their combination therapy were tested with the MTT assay. On the other side, Ce, Fen, and a combination between them were subjected to a colchicine-tubulin binding test, which was conducted and compared to Colchicine as a reference standard. Besides, Ce, Fen, and the combination of them were tested against the VEGFR-2 target receptor, compared to Sorafenib as the standard medication.

Evaluation of the synergistic effect of chitosan metal ions (Cu/Co) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.

The effectiveness of antibiotics that save millions of lives is in danger due to the increasing rise of resistant bacteria around the world. We proposed chitosan-copper ions (CSNP-Cu) and chitosan-cobalt ion nanoparticles (CSNP-Co) as biodegradable nanoparticles loaded with metal ions synthesized an ionic gelation method for treatment of antibiotic resistant bacteria. The nanoparticles were characterized using TEM, FT-IR, zeta potential and ICP-OES.

Synthesis, Characterization, and Biological Evaluation of Cu(II) Complexes Containing Triflupromazine with Glycine and Histidine.

Two novel copper (II) complexes [Cu(TFP)(Gly)Cl] ⋅ 2H O complex (1) and [Cu(TFP)(His)Cl] ⋅ 2H O complex (2) are synthesized, where TFP stands for trifluropromazine, Gly. represents glycine, and His. is histidine.

Single or combined exposure to chlorpyrifos and cypermethrin provoke oxidative stress and downregulation in monoamine oxidase and acetylcholinesterase gene expression of the rat's brain.

The extensive uses of organophosphates and pyrethroids have made it necessary to investigate the neurotoxicity of their combination as they may implicate in the neurodegenerative syndromes. Monoamine oxidase-A (MAO-A) and acetylcholinesterase (AChE) gene expression in the rat brain were evaluated after independent and combined intoxications with chlorpyrifos and cypermethrin. Twenty-four mature male rats were equally distributed into four groups.

Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression.

Pesticides cardiotoxicity in case of diabetic-induced cardiac complications is unidentified. The probable amelioration role of propolis is gauged against the cardiotoxic effects of chlorpyrifos in the diabetic rats through paraoxonase-1 (PON1) and xanthine oxidase (XO) genes dysregulation. Fifty-six male rats were distributed (n = 7) into eight groups.

A novel simple biosensor containing silver nanoparticles/propolis (bee glue) for microRNA let-7a determination.

A novel sensitive electrochemical sensor for microRNAlet-7a detection in normal serum samples, hepatocellular carcinoma patients and human liver cancer cells, has been excellently synthesized. The sensor constructed of carbon paste (CP) amended with silver nanoparticles (AgNPs) and extracted propolis (bee glue). The AgNPs/P modified carbon paste electrode (APCPE) displayed a high electrocatalytic activity in a Britton Robinson (BR) buffer (pH = 7.