Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients.

GATA3 mutations are known to play an important role in breast cancer progression. The exact role and mechanisms of these mutations remain controversial as some studies suggest a relation to breast tumor growth, while others suggest a relation to longer survival. GATA3 germline mutations are not well studied in breast cancer.

MicroRNAs 182 and 375 Sera Expression as Prognostic Biochemical Markers in Breast Cancer.

Introduction: Breast cancer (BC) is the most common malignancy among women; supporting the need for identification of novel prognostic biomarkers, circulating microRNAs (miRNAs) could serve as such in various cancers. The aim of this study was to explore the association between miRNAs 182 and 375 with BC stages and its receptors, based on their expression using real time PCR.

Materials And Methods: Detailed medical history was taken and blood samples were withdrawn from 80 female subjects divided over the studied groups.