Publications by authors named "Heba Farfoura"
Clinical Characteristics and Outcomes of CML in Adolescents and Young Adults.
Clin Lymphoma Myeloma Leuk
October 2024
Article Synopsis
- * The findings revealed that AYAs had higher initial disease severity but showed similar responses to treatment with tyrosine kinase inhibitors (TKIs) as older patients.
- * Although AYAs experienced a shorter event-free survival (EFS), their overall survival (OS) rates were comparable to those of older adults, indicating the need for more research into the unique biology of CML in younger patients.
Background: In early stage diffuse large B-cell lymphoma (ESDLBL), tumor bulkiness is an important determinant of treatment and prognosis. Tumor bulk is usually measured on transverse computed tomography (CT) plane and variably defined from 5 to 10 cm.
Objectives: Our study aims to investigate the prognostic significance of bulky disease measured on CT coronal and transverse planes and to evaluate the outcome of patients with bulky disease.
Most breast cancers are hormone receptor-positive, and tamoxifen is the mainstay of endocrine therapy for such patients. However, with the introduction of aromatase inhibitors and then fulvestrant, tamoxifen became a less preferred drug, even in a premenopausal setting. Many new approaches to tackle the recently identified resistance pathways for endocrine therapy are widely used.
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