Multi-parametric MR imaging using apparent diffusion coefficient and fat fraction in quantification of bone marrow in pediatrics with Gaucher disease.

Purpose: To assess multi-parametric MR imaging with apparent diffusion coefficient (ADC) and fat fraction (FF) in detection and quantification of bone marrow involvement in pediatric patients with Gaucher disease.

Material And Methods: This study was conducted upon 29 pediatric patients with Gaucher disease and 13 age and sex matched controls that underwent diffusion-weighted MR imaging and dual-echo gradient recalled echo imaging. The ADC and FF of the bone marrow were calculated.

Assessment of the liver and spleen in children with Gaucher disease type I with diffusion-weighted MR imaging.

Purpose: To assess hepatic and splenic apparent diffusion coefficient (ADC) in children with Gaucher disease type I with diffusion-weighted MR imaging and to correlate hepatic and splenic ADC with parameters of disease severity.

Subjects And Methods: Prospective study was conducted upon 25 children (11 treated and 14 untreated) with Gaucher disease and 12 age and sex matched control children. They underwent diffusion-weighted MR imaging of abdomen.