Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity.

The undeniable indomethacin potency has always suffered serious obstacles such as gastric damage. Continuous attempts to develop potent yet safe indomethacin analogs have never ceased. Herein are new indole derivatives and , which were synthesized via Fisher indole reaction, evaluated for both their anti-inflammatory activities using rat paw edema method and their cyclooxygenase inhibitory activities.