Publications by authors named "Heba Aboeldahab"
Purpose: Noradrenergics and antimuscarinics have been proposed as future pharmacotherapy for obstructive sleep apnea (OSA). However, the available randomized controlled trials (RCTs) showed heterogeneous results regarding the safety and efficacy of the combined regimen in OSA. Therefore, we performed this meta-analysis from the published RCTs to clarify this conflicting evidence.
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- Acute coronary syndrome (ACS) continues to be a major health challenge globally, even with improved treatment options.
- This study evaluated the impact of empagliflozin, an SGLT2 inhibitor typically used for managing type 2 diabetes, on heart function in ACS patients by analyzing data from four randomized controlled trials with a total of 701 participants.
- Results showed that empagliflozin significantly improved certain left cardiac parameters, like reducing left ventricular end-systolic volume and mass, although it did not significantly change left ventricular ejection fraction or end-diastolic volume, indicating its potential as a complementary treatment in ACS cases.
Article Synopsis
- Rett syndrome (RTT) is a rare genetic disorder that poses significant treatment challenges, and trofinetide has shown promise in improving symptoms in affected individuals.
- A systematic review and meta-analysis of three randomized controlled trials involving 276 patients indicated that trofinetide significantly improved caregiver outcomes and overall clinical measures, particularly in the Rett Syndrome Behavior Questionnaire and Clinical Global Impression Scale.
- While trofinetide showed benefits, it was associated with increased risks of vomiting and diarrhea compared to placebo, highlighting the need to consider its safety profile in clinical use.
Background: Cardiovascular disease (CVD) represents a significant health challenge in Egypt, yet there exists limited understanding regarding the knowledge, attitudes, and physical activity levels associated with CVD. These factors play a pivotal role in developing effective prevention and management strategies. Hence, this cross-sectional study aimed to evaluate Egyptian adults' knowledge, attitudes, and physical activity (KAP) levels.
View Article and Find Full Text PDFIntroduction: Several studies have reported iron accumulation in the basal ganglia to be associated with the development of Parkinson's Disease (PD). Recently, a few trials have examined the efficacy of using the iron-chelating agent Deferiprone (DFP) for patients with PD. We conducted this meta-analysis to summarize and synthesize evidence from published randomized controlled trials about the efficacy of DFP for PD patients.
View Article and Find Full Text PDFBackground: Elevated circulating cholesterol levels in patients with acute coronary syndrome (ACS) increase morbidity and mortality. Recent studies reported that PCSK9 inhibitors (PCSK9i) have a beneficial effect on various domains of patients' lipid profiles and cardiovascular and mortality outcomes. Here, we aim to further investigate the efficacy and safety of PCSK9i in patients with ACS or who experienced recent episodes.
View Article and Find Full Text PDFBackground: During a pandemic, healthcare workers are at high risk of contracting COVID-19. To protect these important individuals, it is highly recommended that they receive the COVID-19 vaccine. Our study focused on evaluating the safety and efficacy of Egypt's first approved vaccine, the Sinopharm vaccine (BBIBP-CorV), and comparing these findings with other vaccines.
View Article and Find Full Text PDFHeart failure (HF) is the most common cardiovascular cause of hospitalization in patients over 60 years, affecting about 64.3 million patients worldwide. Few studies have investigated the role of sodium glucose cotransporter inhibitors (SGLT2Is) in patients with HF without and without diabetes.
View Article and Find Full Text PDFObjectives: To evaluate the analgesic and anti-haemorrhagic efficacy of platelet-rich plasma (PRP) among patients undergoing tonsillectomy.
Design: A systematic review and meta-analysis of randomised controlled trials (RCTs).
Setting: PubMed, Scopus, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases were screened from inception until July 2021, and updated in December 2021.