Publications by authors named "Heather V Dowty"
Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected.
View Article and Find Full Text PDFArticle Synopsis
- In drug design, it's crucial to identify structural alerts that could lead to toxicity issues.
- This study demonstrated that trifluoroethane in a new chemical compound caused testicular toxicity in rats due to the production of trifluoroacetaldehyde, a known toxic substance.
- Comparative tests with a different chemical structure (N-tetrazole instead of N-trifluoroethane) showed no testicular damage, emphasizing the importance of early safety assessments in drug development.
Tamoxifen (TAM), an antiestrogenic compound, has been approved for the treatment of breast cancer in high risk women. TAM has been shown to be an effective agent for prevention of breast cancer in women of varying degrees of risk and has been proposed to be used prophylactically in women whose genetic background suggests a high risk for breast cancer. However, it is not known whether TAM given prophylactically will alter the response of women to carcinogens from common environmental exposures such as tobacco smoke.
View Article and Find Full Text PDF