Lung tumor motion change during stereotactic body radiotherapy (SBRT): an evaluation using MRI.

The purpose of this study is to investigate changes in lung tumor internal target volume during stereotactic body radiotherapy treatment (SBRT) using magnetic resonance imaging (MRI). Ten lung cancer patients (13 tumors) undergoing SBRT (48 Gy over four consecutive days) were evaluated. Each patient underwent three lung MRI evaluations: before SBRT (MRI-1), after fraction 3 of SBRT (MRI-3), and three months after completion of SBRT (MRI-3m).

Evaluation of kV cone-beam ct performance for prostate IGRT: a comparison of automatic grey-value alignment to implanted fiducial-marker alignment.

Purpose: Cone-beam computed tomography (CBCT) is a new image-guided radiation therapy (IGRT) technique for patient alignment in radiotherapy. The CBCT x-ray volume imaging system from Elekta allows for a variety of alignment methods. The aim of this study is to assess the accuracy of soft-tissue-based automatic alignment as compared with manual alignment using intraprostatic fiducials.

Squamous cell carcinoma of the anal margin: the university of Florida experience.

Objective: To update our experience in treating squamous cell carcinoma of the anal margin with definitive radiotherapy (RT).

Methods: A total of 26 patients treated curatively with RT between 1979 and 2008, with or without concurrent chemotherapy, were retrospectively reviewed. American Joint Committee on Cancer stage distribution was: T1, N = 1; T2, N = 16; T3, N = 9; N0, N = 25; and N1, N = 1.

Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer.

Background: Both concomitant chemotherapy and altered fractionation radiotherapy (RT) have been shown to improve outcomes for patients with locoregionally advanced head and neck squamous cell carcinomas. However, both strategies also increase acute toxicity, and it is questionable whether the 2 can be safely combined. Traditional concomitant chemotherapy regimens include high-dose cisplatin given at 100 mg/m2 every 3 weeks.

Optimal image-guidance scenario with cone-beam computed tomography in conventionally fractionated radiotherapy for lung tumors.

Purpose: To determine the residual setup errors of several image guidance scenarios, using cone-beam computed tomography (CBCT) in conventionally fractionated radiotherapy for lung tumors.

Methods: Thirteen lung cancer patients were treated with conventionally fractionated radiotherapy, using daily image guidance with CBCT, resulting in 389 CBCT scans which were registered to the planning scan using automated soft-tissue registration. Using the resulting daily alignment data, 4 imaging frequency scenarios were analyzed: (A) no imaging; (B) weekly imaging with a 3-mm threshold; (C) first 5 fractions imaged, then weekly imaging with a patient-specific threshold; and (D) imaging every other day.

The effect of intravenous contrast on photon radiation therapy dose calculations for lung cancer.

Objective: The aim of this study was to evaluate the effect of intravenous contrast-enhanced computed tomography (CT) scans on the photon radiation dose calculations for lung cancer treatment planning.

Materials And Methods: Nonionic iodinated intravenous contrast (Iohexol) was administered during the treatment planning CT scan of 9 patients with node-positive non-small-cell lung cancer (NSCLC). The potential effect of intravenous contrast was studied by changing the density of the contrast-enhanced vessels.

Does surgical closure technique affect early mammographic detection of tumor recurrence after breast-conserving therapy?

Purpose: Scarring in the tumor bed may mask or mimic local recurrence of tumor on surveillance mammography. Type of surgical closure technique used during lumpectomy may impact the pattern or density of scar tissue apparent in the tumor bed on mammography. This study sought to determine whether surgical closure type affects tumor-bed scar formation and impacts interpretation of surveillance mammography in women treated with breast-conserving therapy for early-stage breast cancer.

Tumor localization using cone-beam CT reduces setup margins in conventionally fractionated radiotherapy for lung tumors.

Purpose: To determine whether setup margins can be reduced using cone-beam computed tomography (CBCT) to localize tumor in conventionally fractionated radiotherapy for lung tumors.

Methods And Materials: A total of 22 lung cancer patients were treated with curative intent with conventionally fractionated radiotherapy using daily image guidance with CBCT. Of these, 13 lung cancer patients had sufficient CBCT scans for analysis (389 CBCT scans).

Unresectable squamous cell carcinoma of the lung: an outcomes study.

Purpose: To report survival and control rates in patients with inoperable squamous cell carcinoma (SCC).

Methods And Materials: Two hundred seventy-five patients with inoperable squamous cell carcinoma of the lung (Stages I-IIIB) who received radiotherapy alone or combined with chemotherapy given with curative intent at the University of Florida between 1963 and 2006 were retrospectively analyzed.

Results: Overall survival (OS) at 5 years for Stages I, II, and III was 10%, 14%, and 7% (p = 0.

Association between operative closure type and acute infection, local recurrence, and disease surveillance in patients undergoing breast conserving therapy for early-stage breast cancer.

Background: This study investigates the effect of full-thickness versus superficial closure of the breast parenchyma on the likelihood of subsequent infection and local recurrence after lumpectomy for early-stage breast cancer. In patients undergoing breast-conserving therapy (BCT), operative closure technique has been largely influenced by expected cosmetic outcome. However, the common practice of promoting postoperative fluid collection raises concerns about potential bacterial colonization, tumor cell migration, and impaired post-BCT surveillance.

Delayed breast cellulitis: an evolving complication of breast conservation.

Purpose: Delayed breast cellulitis (DBC) is characterized by the late onset of breast erythema, edema, tenderness, and warmth. This retrospective study analyzes the risk factors and clinical course of DBC.

Methods And Materials: From 1985 through 2004, 580 sequential women with 601 stage T0-2N0-1 breast cancers underwent breast conserving therapy.

Neurotropic melanoma of the head and neck with clinical perineural invasion.

Objective: The purpose of this article is to report our experience with neurotropic melanoma, a rare malignancy that sometimes produces neurologic symptoms because of a direct extension of the primary tumor.

Methods: We report 3 consecutive patients with neurotropic melanoma of the head and neck who presented with clinical perineural invasion.

Results: Two patients had incompletely resectable tumors and were treated with definitive radiotherapy (RT), and 1 patient received surgery and postoperative RT.

Plasma cell granuloma of the maxillary sinus: a case report and literature review.

Background: Plasma cell granulomas are rare and heterogeneous tumor-like lesions of mixed inflammatory cell infiltrates of unknown etiology. Although they have the potential to occur in sites throughout the body, their occurrence in the paranasal sinuses and nasal cavity is uncommon and often associated with unique clinical characteristics and natural history.

Methods: We present a case of an aggressive plasma cell granuloma of the maxillary sinus and a review of the literature (28 cases).

Squamous cell carcinoma of the anal margin.

Purpose: To define the optimal treatment of patients with squamous cell carcinoma (SCCA) of the anal margin.

Methods: Nineteen patients treated with curative intent by radiotherapy (RT) alone or combined with adjuvant chemotherapy (CTX) between 1979 and June 2000 were analyzed. The pertinent literature was reviewed and discussed as it related to our experience.