Effect of topical vitamin D analogue on in vivo contact sensitization.

Background: The immunomodulatory role of vitamin D and its analogues has been demonstrated in vitro and in vivo using animal models. We evaluated the effect of a vitamin D analogue, calcipotriene, in vivo on human subjects using a contact hypersensitivity model.

Observations: Subjects were pretreated with topical calcipotriene, simulated solar radiation, or both on buttock skin.