Hyperpolarized Sodium [1-C]-Glycerate as a Probe for Assessing Glycolysis In Vivo.

Hyperpolarized C magnetic resonance spectroscopy (MRS) provides unprecedented opportunities to obtain clinical diagnostic information through in vivo monitoring of metabolic pathways. The continuing advancement of this field relies on the identification of molecular probes that can effectively interrogate pathways critical to disease. In this report, we describe the synthesis, development, and in vivo application of sodium [1-C]-glycerate ([C]-Glyc) as a novel probe for evaluating glycolysis using hyperpolarized C MRS.