Oral versus topical diclofenac for pain prevention during panretinal photocoagulation.

Purpose: To investigate the effect of pretreatment oral and topical diclofenac on pain reduction during panretinal laser photocoagulation (PRP) for proliferative diabetic retinopathy (PDR).

Design: Prospective, randomized, double-masked, placebo-controlled clinical trial.

Participants And Controls: A total of 90 patients with PDR requiring PRP for the first time were assigned randomly to 1 of 3 study groups: oral diclofenac (n = 30), topical diclofenac (n = 31), or placebo (n = 29).