Publications by authors named "Heather L Murphey"

Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of amyloid-β (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD.

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Article Synopsis
  • The study examined how age and antioxidant treatment affect cognitive decline in beagles over three years.
  • Young and aged dogs were matched and divided into treatment groups, where antioxidant treatment improved performance in aged dogs during initial learning tasks.
  • While treated aged dogs showed some improvement, young dogs consistently performed better on later tasks, indicating that antioxidants selectively help with specific aspects of age-related cognitive decline rather than overall cognitive function.
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Beagle dogs exhibited diurnal patterns of locomotor activity that varied as a function of age, cognitive status, and housing environment. Aged dogs housed in an indoor facility showed a delayed onset of activity following lights on and displayed shorter bouts of activity, with more rest periods during the day, compared with young dogs. Cognitively impaired aged dogs were more active and showed a delayed peak of activity compared with unimpaired aged dogs.

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A decrease in motor activity is an expected concomitant of normal aging and has been reported in humans and nonhuman mammals. We have previously failed to find age differences in open-field locomotor activity in beagle dogs. We now report an age-associated decline when activity measures are taken in the home cage.

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