CE: Addressing Food Insecurity in Vulnerable Populations.

: Food insecurity affects people of all ages, in every area in which nurses work or volunteer. The U.S.

Investigation into temperature-induced aggregation of an antibody drug conjugate.

Conjugation of an antibody to a drug can produce heterogeneous species that may have different physical stabilities and safety profiles. We explored the effect of thermal stress on the physical stability, specifically aggregation, of an antibody drug conjugate (ADC), ADC 1, wherein the antibody was linked to the val-cit-Monomethyl Auristatin E (vc-MMAE) linker drug through the reduction of interchain disulfides. We also explored the effects of conjugation on the secondary and tertiary structures of ADC 1.