Publications by authors named "Heather Giza"
Pancreatic ductal adenocarcinoma (PDAC) is a drug resistant and lethal cancer. Identification of the genes that consistently show altered expression across patients' cohorts can expose effective therapeutic targets and strategies. To identify such genes, we separately analyzed five human PDAC microarray datasets.
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- H3K27M diffuse midline gliomas (DMG) consist of two main types of cells: less-differentiated oligodendrocyte precursor-like stem cells and more differentiated astrocyte-like cells.
- Researchers created models representing these cell types and used various profiling techniques to understand their distinct metabolic programs, identifying specific weaknesses in each type.
- The study found that astrocyte-like cells are more prone to a type of cell death called ferroptosis, while oligodendrocyte precursor-like cells are sensitive to statins and inhibitors of mitochondrial function, suggesting targeted therapies could improve treatment outcomes for patients with these tumors.
Often referred to as the bridge between innate and adaptive immunity, dendritic cells (DCs) are professional antigen-presenting cells (APCs) that constitute a unique, yet complex cell system. Among other APCs, DCs display the unique property of inducing protective immune responses against invading microbes, or cancer cells, while safeguarding the proper homeostatic equilibrium of the immune system and maintaining self-tolerance. Unsurprisingly, DCs play a role in many diseases such as autoimmunity, allergy, infectious disease and cancer.
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