Optimization and characterization of miRNA-129-5p-encapsulated poly (lactic--glycolic acid) nanoparticles to reprogram activated microglia.

Microglia have become a therapeutic target of many inflammation-mediated diseases in the central nervous system (CNS). Recently, microRNA (miRNA) has been proposed as an important regulator of immune responses. Specifically, miRNA-129-5p has been shown to play critical roles in the regulation of microglia activation.