Publications by authors named "Heather Breen"

Obesity has become an epidemic in the United States, with other western countries also reporting increases in incidence of obesity. With many associated comorbidities, it is the most common nutritional disorder facing the medical team. However, the assessment of macronutrient needs for nutrition support regimens in obese adults is controversial.

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Background: The human aldehyde dehydrogenase-2 promoter contains sites that bind members of the nuclear receptor family, and one (designated FP330-3') is predicted to bind retinoic acid receptors.

Methods: Binding of retinoid receptors to the FP330-3' oligonucleotide duplex and point mutations thereof was assayed using electrophoretic mobility shift assays. The function of the promoter element was determined in transfection assays.

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