Publications by authors named "He-lin Ding"
Article Synopsis
- Oncocytic thyroid carcinoma (OTC) is a rare and aggressive form of thyroid cancer with a high chance of recurrence, differing significantly from follicular thyroid carcinoma (FTC).
- A study analyzed 2,329 OTC and 5,679 FTC patients using the SEER database to compare their clinicopathological features and survival outcomes, employing various statistical methods like Kaplan-Meier analysis and Cox regression.
- Results indicated that OTC patients generally experienced lower overall and cancer-specific survival rates compared to FTC patients, particularly in specific demographic and clinical subgroups, emphasizing the need for more targeted research on OTC.
Background: The decreased degradation of extra-cellular matrix proteins plays an important role in the onset of diabetic nephropathy. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1), which are members of the matrix metalloproteinase family, are associated with this process. Angiotensin II (AII) plays an important role in the development of diabetic nephropathy also.
View Article and Find Full Text PDFBackground And Objectives: The renin-angiotensin system plays a critical role in circulatory homoeostasis. Evidence has emerged that suggests a pathologic role for angiotensin II in patients with kidney disease. Losartan is an antagonist of angiotensin II and blocks the angiotensin II type-1 receptor.
View Article and Find Full Text PDF[Effects of losartan on the levels of angiotensin II and its type-1 receptor in diabetic rat kidney].
Nan Fang Yi Ke Da Xue Xue Bao
December 2006
Objective: To investigate the effect of losartan, an angiotensin II type-1 receptor (AT1R) antagonist, on the levels of angiotensin II (Ang II) and AT1R in diabetic rat kidney.
Methods: Male Wistar rats were divided into 3 groups, group A (n=11) served as the control group, group B (n=11) included the diabetic rats (induced by intraperitoneal injection of streptozotocin) without any therapy, and group C (n=9) diabetic rats treated with losartan. After 18 weeks of treatment, the kidneys were taken from all the rats to measure the expression of AT1R mRNA by RT-PCR and detect the Ang II level.