Publications by authors named "He-Zhuang Liao"
Trends and disease burden of enteric fever in Guangxi province, China, 1994-2004.
Bull World Health Organ
September 2010
Article Synopsis
- The study aimed to assess the burden of enteric fever in Guangxi, China, by analyzing morbidity and mortality trends, bacterial species involved, and antimicrobial resistance over a ten-year period from 1994 to 2004.
- Data was collected from disease control centers and included an examination of outbreaks, with a focus on underreporting in different regions to gain an accurate incidence rate of enteric fever.
- Findings revealed that enteric fever peaked in 1995 at 13.5 cases per 100,000 population, with summer and autumn being the most affected seasons; the predominant bacterial species was identified as Salmonella paratyphi A, prompting the need for improved treatment strategies and potential vaccine development.
Objective: To assess the safety, immunogenicity and efficacy of group A and C meningococcal polysaccharide vaccine (A/C MPV) in response to an outbreak of group C meningococcal disease.
Methods: A vaccination campaign with A/C MPV was prompted 6 weeks after the use of group A MPV in Laibin city, Guangxi, where an outbreak of group C meningococcal meningitis occurred in 2002. Vaccinees were observed for local and systemic reactions after the vaccination and followed up for the meningococcal disease for 5 years.
[Evaluation on the safety of a group A + C meningococcal polysaccharide vaccine].
Zhonghua Liu Xing Bing Xue Za Zhi
May 2007
Objective: To evaluate the safety of a group A + C meningococcal polysaccharide vaccine as part of a phase IV clinical trial.
Methods: The study area was divided into 108 clusters according to the principle of cluster randomization, stratified and paired sampling methods. 54 out of 108 clusters served as observation groups were administered A + C vaccine, while the rest 54 groups were administered Vi polysaccharide vaccine.
[Application of cluster randomization method on typhoid Vi vaccine trails].
Zhonghua Liu Xing Bing Xue Za Zhi
February 2005
Objective: To describe the design and application of cluster randomized controlled method on typhoid Vi vaccine trial, and to assess the effect of implementation.
Methods: Simple size calculation of cluster-randomized trial was used to determine the sample size of the two groups and a vaccination campaign was conducted. The study group was given typhoid Vi vaccine and the control group was given meningococcal A vaccine.
Background: One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China.
Methods: The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines.
Objective: To characterize the incidence, epidemiologic features, etiologic agents and sequelae of bacterial meningitis in children under 5 years of age in Nanning, Guangxi.
Methods: A population-based surveillance was conducted to evaluate children with signs and symptoms of meningitis. All hospitals, township health centers and village clinics in the surveillance area were structured to participate in the case referral and evaluation.