A reliable graded acute liver failure model in rats: treatment with internal bioartificial liver.

Background: Appropriate animal models are important for studying acute liver failure. This study was to assess a new suitable rat model for acute liver failure.

Methods: After the right influent hepatic vessels were clamped for a period of time (45, 60 or 90 minutes respectively), the animal model was established by removal of the clamp for restoring blood flow of the right lobes while immediately removal of the median, left lateral and caudate lobes.

The development of a new bioartificial liver and its application in 12 acute liver failure patients.

Aim: Bioartificial liver is a hope of supporting liver functions in acute liver failure patients. Using polysulfon fibers, a new bioartificial liver was developed. The aim of this study was to show whether this bioartificial liver could support liver functions or not.