THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation.

Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus characterized by heart failure and cardiac remodeling. Previous studies show that tetrahydroberberrubine (THBru) retrogrades cardiac aging by promoting PHB2-mediated mitochondrial autophagy and prevents peritoneal adhesion by suppressing inflammation. In this study we investigated whether THBru exerted protective effect against DCM in db/db mice and potential mechanisms.

The human health burden of non-typhoidal Salmonella enterica and Vibrio parahaemolyticus foodborne gastroenteritis in Shanghai, east China.

Information on the burden of disease due to foodborne pathogens in China is quite limited. To understand the incidence of foodborne gastroenteritis due to non-typhoidal Salmonella enterica and Vibrio parahaemolyticus, population survey and sentinel hospital surveillance were conducted during July 2010 to June 2011 in Shanghai, east China, and a model for calculating disease burden was established. The multiplier for gastroenteritis caused by these pathogens was estimated at 59 [95% confidence interval (CI) 30-102].

[Effect of Organic Fertilizer and Inorganic Fertilizer Application on NO Emissions from Fluvo-aquic Soil in the North China Plain].

The North China Plain is an important grain production area in China. Due to the low content of soil organic carbon, increasing the application rate of nitrogen fertilizer would not lead to a continuous increase of maize yield at present. The combined application of organic fertilizer and inorganic fertilizer is widely regarded as a measure to simultaneously increase grain yield and soil organic carbon; however, the effect of organic fertilizer and inorganic fertilizer application on NO emissions from farmland in the North China Plain is unclear.

Sleep disorders in multiple sclerosis in China: clinical, polysomnography study, and review of the literature.

Sleep disorders are common in multiple sclerosis (MS). The aim of this study was to assess the subjective and objective sleep disturbances in patients with MS and to investigate their relationships with fatigue and excessive daytime sleepiness. All participants completed standardized questionnaires and underwent nocturnal polysomnography.

[Prevalence of REM sleep behavior disorder in patients with brainstem lesions].

Objective: To explore the prevalence of REM sleep behavior disorder (RBD) and define the brainstem structures likely to be involved in its pathogenesis in patients with brainstem lesions on magnetic resonance imaging (MRI).

Methods: Sixty-two patients with definite brainstems lesions on brain MRI were recruited from Neurology Department, Peking Union Medical College Hospital. And 66 gender-and-age-matched healthy subjects were included as controls.

[The correlation between the electroencephalogram findings and clinical manifestations of Creutzfeldt-Jakob disease].

Objective: To investigate the correlation between the EEG findings and the clinical signs of Creutzfeldt-Jakob disease (CJD).

Methods: Serial standard recording during different stage of disease was conducted among 13 patients with CJD, 10 males and 3 females, with the year of onset of 58.2 (49 approximately 65).