Publications by authors named "He-Wen Wu"
Purpose: Surgery for esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and high complication rate, resulting in a heavy symptom burden and poor health-related quality of life (QOL). We evaluated longitudinal patient-reported outcomes (PROs) to analyze the correlations between symptoms and QOL and their changing characteristics during postoperative rehabilitation.
Methods: We investigated patients with ESCC who underwent minimally invasive McKeown esophagectomy at Sichuan Cancer Hospital between April 2019 and December 2019.
Article Synopsis
- The study compared the effects of neoadjuvant immunochemotherapy (NICT) and neoadjuvant chemoradiotherapy (NCRT) on esophageal squamous cell carcinoma (ESCC) in 28 patients divided into two groups for treatment.
- It evaluated the expression and changes of PD-L1, a protein linked to immune response, finding that both treatments increased PD-L1 levels, with NCRT causing a more significant rise compared to NICT.
- Although NICT was not less effective than NCRT in terms of tumor response, the study concluded that preoperative PD-L1 scores were not good predictors of treatment effectiveness, while changes in PD-L1 expression (specifically IPS) could be linked to the
PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy.
Ecotoxicol Environ Saf
January 2019
Background: The increasing epidemic of fine particulate matter (PM2.5) is a serious threat to human health. It induces the occurrence of liver fibrosis, but its molecular mechanism is not yet clear.
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