Prognostic Factors and a Nomogram Predicting Survival in Patients with Breast Ductal Carcinoma in situ with Microinvasion: A Population-Based Study.

Purpose: Ductal carcinoma in situ with microinvasion (DCISM) can be challenging to balance the risks of overtreatment versus undertreatment. We aim to identify prognostic factors in patients with DCISM and construct a nomogram to predict breast cancer-specific survival (BCSS).

Materials And Methods: A retrospective cohort study of women diagnosed with DCISM from 1988 to 2015 who were identified in the Surveillance, Epidemiology and End Results database.

Biflavonoids from the twigs and leaves of Mast. and their -glucosidase inhibitory activity.

Three new biflavonoids, umcephabiovins C - E (), along with fourteen known compounds were isolated from the twigs and leaves of . Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds exhibited significant -glucosidase inhibitory activity with IC values of 7.

The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.

Metastasis is a major cause of death in patients with breast cancer. Stathmin1 (STMN1) is a phosphoprotein associated with cancer metastasis. It exhibits a complicated phosphorylation pattern in response to various extracellular signals, but its signaling mechanism is poorly understood.

[Mechanism of avian sex determination and differentiation].

Avian sex is determined by genes on the sex chromosomes (ZZ for male and ZW for female). In avian embryo stage, genes on one or two chromosomes control the sex differentiation. Gonad develops to testis in ZZ male and to ovary in ZW female.

[cDNA cloning and protein structure analysis of growth hormone from Clarias lazera].

Total RNA was isolated from pituitary gland of Clarias lazera, and the cDNA encoding growth hormone (GH) protein was amplified and cloned by reverse transcription polymerase chain reaction (RT-PCR). The open reading frame (ORF) of cDNA is of 603 nt which encodes GH precursor consisted of a signal peptide with 22 amino acid residues and a mature peptide with 178 amino acid residues. Sequence alignment indicated that the amino acid sequence homology approached to 95.

[Intraspecific DNA sequence polymorphism and genetic markers in the mitochondrial CO I gene from three populations of Macrobrachium rosenbergii].

The mitochondrial COI gene was PCR amplified and sequenced from 17 samples obtained from three populations of Macrobrachium rosenbergii (F1 of the Burma wildtype population, Jiangsu cultured population and F2 of the Guangxi breeding population). A 498-bp long partial gene segment was acquired and used to study the genetic diversity among the three populations. Results indicated that the COI gene locus was relatively more polymorphic in the F1 of Burma wildtype population, while the polymorphism in Jiangsu cultured population and Guangxi breeding population were very poor.