Publications by authors named "He-Qun Zou"
GDF11 Improves Ischemia-Reperfusion-Induced Acute Kidney Injury via Regulating Macrophage M1/M2 Polarization.
Kidney Blood Press Res
January 2024
Introduction: Acute kidney injury (AKI) is a clinical emergency caused by the rapid decline of renal function caused by various etiologies. Growth differentiation factor 11 (GDF11) can promote renal tubular regeneration and improve kidney function in AKI, but the specific mechanism remains unclear. Herein, we investigated the effect and mechanisms of GDF11 in ameliorating AKI induced by ischemia-reperfusion (I/R).
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- The study aimed to create and validate a prediction score for cardiovascular disease (CVD) risk specifically for hemodialysis patients in China.
- It involved 388 patients over a follow-up period, identifying key predictors like age, hypertension, diabetes, and abnormal white blood cell count that were included in the final model.
- The prediction score demonstrated reliable performance in distinguishing high-risk patients, suggesting it can help healthcare providers target at-risk individuals for better treatment strategies.
Article Synopsis
- The study investigates the link between high-sensitivity C-reactive protein (hs-CRP) levels and the development of metabolic syndrome (MetS) in a Chinese population over five years.
- It found that 13.3% of participants developed MetS, with higher hs-CRP levels significantly associated with increased risk, particularly in women (OR: 4.82) but not in men (OR: 3.15).
- The findings suggest that hs-CRP may be a useful target for predicting and addressing MetS, emphasizing the need for sex-specific approaches in future research.
Article Synopsis
- * The review analyzed studies from various databases, highlighting the rich content of proteins and microRNAs found in uEVs that are involved in kidney health.
- * While there's no standard method for isolating uEVs, they are recognized as valuable indicators for diagnosing DKD and could serve as therapeutic targets for managing the disease.
[Association of waist-to-hip ratio with insulin resistance in non-diabetic normal-weight individuals: a cross-sectional study].
Nan Fang Yi Ke Da Xue Xue Bao
November 2017
Article Synopsis
- The study investigates the link between waist-to-hip ratio (WHR) and insulin resistance (IR) in non-diabetic, normal-weight individuals, focusing on how this varies between genders.
- Researchers conducted a survey of 2142 non-diabetic Chinese participants and used the HOMA-IR method to measure insulin resistance.
- Results showed a strong correlation between higher WHR and insulin resistance in women, even after adjusting for other health factors.
Article Synopsis
- - The study aimed to explore the link between the hypertriglyceridemic waist-to-height ratio phenotype (HWHtR) and chronic kidney disease (CKD) among residents in Zhuhai, China, analyzing data from over 2,100 participants.
- - Participants were classified into HWHtR and non-HWHtR groups based on specific waist-to-height and triglyceride levels, with results showing a significantly higher prevalence of CKD in the HWHtR group (33% vs 11.1%, P<0.001).
- - Logistic regression analysis indicated that HWHtR is strongly associated with CKD, revealing that this relationship remains significant even after adjusting for various health and demographic
[Clinical and pathological features in IgA nephropathy with IgG deposition in the glomerular mesangial area].
Nan Fang Yi Ke Da Xue Xue Bao
March 2017
Article Synopsis
- The study aimed to explore the link between clinical and pathological features in patients with IgA nephropathy, focusing on those with and without IgG deposition in the kidneys.
- Data were collected from 122 patients diagnosed with IgA nephropathy, categorized into two groups based on IgG presence, and analyzed using various microscopy techniques.
- Results indicated that patients with IgG deposition experienced worse clinical symptoms and more significant kidney damage, suggesting the need for targeted interventions to manage IgG levels in these patients.
[Association of waist-to-hip ratio with chronic kidney disease in non-diabetic subjects].
Nan Fang Yi Ke Da Xue Xue Bao
August 2016
Article Synopsis
- The study investigates the link between waist-to-hip ratio (WHR) and chronic kidney disease (CKD) among non-diabetic individuals, focusing on differences between genders.
- A survey of 2,142 southern Chinese participants revealed that higher WHR was significantly associated with CKD in women, even after adjusting for various health factors.
- In contrast, the findings did not show a significant relationship between WHR and CKD in non-diabetic men.
[Detection of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy].
Nan Fang Yi Ke Da Xue Xue Bao
April 2015
Article Synopsis
- The study aimed to determine how common the PLA2R1 antigen is in kidney biopsy samples from patients with idiopathic membranous nephropathy (IMN) and to understand its connection to the disease.
- Out of 108 patients, 41 were diagnosed with IMN, and an immunofluorescence assay revealed that 85.37% of those with IMN tested positive for the PLA2R1 antigen, while it was absent in other types of kidney diseases.
- Despite the high prevalence of PLA2R1 in IMN patients, the research found no significant differences in clinical measures like age or protein levels between those who were positive and negative for the antigen.
Article Synopsis
- A study in Zhuhai City, China, examined the prevalence of metabolic syndrome (MetS) and the effects of exercise, smoking, and education on its risk among 4,645 adults aged 18-75 years.
- The results showed that 19.8% of participants had MetS, with smokers at higher risk (adjusted odds: 1.61) and those not exercising enough (less than 60 minutes/day) also at risk (adjusted odds: 1.51).
- Additionally, education positively influenced MetS risk, as individuals with higher education levels showed lower odds of developing the syndrome compared to those with no education.
Article Synopsis
- A community-based screening study in Southern China was conducted to determine the prevalence of chronic kidney disease (CKD) and prediabetes among 7801 residents.
- The study found an age-standardized prevalence of CKD at 12.5% and prediabetes at 12.1%, with insulin resistance identified as a significant independent risk factor for both conditions.
- The findings highlight the growing public health concern of CKD and prediabetes in the region, suggesting a need for increased awareness and intervention strategies.
[Expression of MMP-2 and TIMP-1 in renal tissues of patients with chronic active antibody-mediated renal graft rejection].
Nan Fang Yi Ke Da Xue Xue Bao
December 2011
Article Synopsis
- The study aimed to investigate the levels of two proteins, MMP-2 and TIMP-1, in kidney transplants from patients experiencing chronic antibody-mediated rejection (ABMR).
- Researchers analyzed kidney samples from 46 patients with fibrosis and 15 healthy controls using immunohistochemistry techniques.
- Results showed higher levels of MMP-2 and TIMP-1 in the affected tissues, indicating a link between these proteins and the worsening of kidney damage in ABMR.
[A pilot study of using pure albumin as a dialysate in the treatment of liver failure].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
October 2005
Article Synopsis
- The study aims to assess the effects of single albumin dialysis (SAD) compared to the molecular absorbent recycling system (MARS) in treating liver failure patients.
- Eighteen patients were treated with either SAD or MARS for 6 hours, monitoring various liver and kidney functions, as well as other critical health markers throughout the sessions.
- Results indicated that SAD significantly improved clinical symptoms and liver function with fewer complications and at a lower cost than MARS, suggesting it is a viable option for treating liver failure and warrants further research.
Article Synopsis
- The study aims to explore the expression of matrix metalloproteinase-9 (MMP-9) in the kidneys of rats suffering from chronic allograft nephropathy (CAN).
- Researchers conducted kidney transplants between specific rat strains and analyzed the transplanted kidneys after 12 weeks for pathology and protein expression.
- Results showed that MMP-9 and TGF-beta1 levels were significantly elevated in the rats with CAN compared to control groups, indicating a potential link between these proteins and disease severity.
Article Synopsis
- A serosurvey tested 1,147 healthcare workers in 3 hospitals to check for antibodies to the SARS virus, aiming to understand how widespread inapparent infections were among them.
- Out of 90 workers who had SARS, 88.9% showed evidence of past infection, while only 1.4% of apparently healthy workers had antibodies.
- The low seroprevalence in a reference group indicates that inapparent infections are rare, highlighting the importance of personal protective measures in healthcare settings to prevent future outbreaks.