Publications by authors named "He-Ning Cui"
G3 (Bethesda)
January 2019
Article Synopsis
- The neuromuscular junction (NMJ) is made up of motor neurons, muscle fibers, and Schwann cells, which are crucial for its development.
- Conditional inactivation of specific genes in Schwann cells in mice led to delayed NMJ maturation and muscle growth, mirroring symptoms of muscular dystrophy seen in neurofibromatosis type I.
- Analysis of the affected Schwann cells revealed disrupted signaling pathways, particularly hyperactive RAS/PI3K/AKT/mTOR, indicating their critical role in NMJ and muscle development.
