Publications by authors named "He-Kun Jin"
Among the thirteen leukocyte Ig-like receptor (LILR) loci located at 19q13.4, LILRA3 is unique in that it encodes a soluble protein lacking the transmembrane and cytoplasmic domains, and a 6.7 kb deletion spanning the first seven exons has been detected in some human individuals.
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- The study analyzed 1,105 nasopharyngeal carcinoma (NPC) cases and 1,430 normal controls from Hunan province, China, to investigate associations with human leukocyte antigen (HLA) variants.
- Strong positive links were found between NPC and certain HLA alleles (like HLA-B*46:01), while five rare alleles showed strong negative associations, suggesting they may confer protection against NPC.
- A significant difference in antivirus capsid antigen immunoglobulin A (anti-VCA IgA) levels was noted between NPC cases and controls, but no direct link was found between HLA-B variations and these antibody levels; the results highlight unique genetic factors influencing NPC risk in southern Chinese populations.
Deletion of major histocompatibility complex class I chain-related genes A (MICA*Del) was investigated in 3,411 DNA samples from two southern Chinese Han populations (Hunan Han, HNH; Guangdong Han, GDH), two northern Chinese populations (Inner Mongolia Han, IMH; Inner Mongolia Mongol, IMM) and one southeastern Chinese Han population (Fujian Han, FJH) using an in-house polymerase chain reaction-sequence specific priming (PCR-SSP) assay, which enables direct discrimination between heterozygote and homozygote for MICA*Del. MICA*Del showed a frequency ranging from 0.8% in FJH to 5.
View Article and Find Full Text PDFIn this study, copy number variation (CNV) of NKG2C gene was investigated in 1129 normal, unrelated individuals representing two southern Chinese Han populations (Hunan Han and Guangdong Han), two northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol) and one southeastern Chinese Han population (Fujian Han) using polymerase chain reaction-sequence-specific priming (PCR-SSP) method. CNV of NKG2C gene did not vary significantly among the five Chinese populations, with NKG2C gene deletion showing a frequency ranging from 0.2031 to 0.
View Article and Find Full Text PDFMagnetic fluid hyperthermia (MFH) induced by a magnetic field has become a new heating technology for the treatment of malignant tumors due to its ability to heat the tumor tissue precisely and properly, and due to its significant therapeutic effects. In this study, MFH induced by radiofrequency capacitive field (RCF) for the treatment of transplanted subcutaneous tumors in rats, was investigated. A total of 50 rats bearing subcutaneous tumors were randomly divided into five groups, including i) a pseudo-treatment (PT) control group, ii) magnetic fluid (MF) group, iii) pure hyperthermia (PH) group, iv) magnetic fluid hyperthermia 1 (MFH1) group, and v) magnetic fluid hyperthermia 2 (MFH2) group.
View Article and Find Full Text PDFRadiation-induced side effects on normal tissue are determined largely by the capacity of cells to repair radiation-induced DNA damage. X-ray repair cross-complementing group 1 (XRCC1) plays an important role in the repair of DNA single-strand breaks. Studies have shown conflicting results regarding the association between XRCC1 gene polymorphisms (Arg399Gln, Arg194Trp, -77T>C and Arg280His) and radiation-induced side effects in patients undergoing whole breast radiotherapy.
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- - Previous studies linked specific HLA-B types (like HLA-B35 and HLA-B38) to increased risk of nasopharyngeal carcinoma (NPC) in Chinese populations, suggesting genetic factors influence susceptibility to this cancer.
- - The MICA gene, which is adjacent to HLA-B and plays a role in immune response, was hypothesized to be associated with NPC; researchers analyzed its variants in 218 NPC patients and 196 healthy controls.
- - Results showed that the MICA*A9 variant was significantly more common in NPC patients, while MICA*A5.1 was less frequent, especially among males, highlighting a potential gender-specific genetic risk factor for NPC.
Objective: To explore the association between the short tandem repeat polymorphism of exon 5 of MICA gene (MICA-STR) and nasopharyngeal carcinoma (NPC) in a southern Chinese population.
Methods: One hundred and twenty-seven consecutive NPC patients and 112 randomly selected normal controls residing in southern China mainland were analyzed for MICA-STR allelic variation and MICA gene deletion by fluorescent polymerase chain reaction-gene scanning and polymerase chain reaction-sequence specific priming.
Results: MICA*A9 was observed at significantly higher frequency in the NPC patient group than in the control group (relative risk = 2.