Publications by authors named "He-Kai Chen"
Article Synopsis
- The study investigates the role of circulating microRNA-212 (miR-212) as a potential biomarker for gastric cancer by comparing its serum levels in healthy individuals versus gastric cancer patients.
- Results showed that miR-212 levels were higher in healthy individuals and gastric mucosal cells, while lower levels correlated with gastric cancer, indicating it could be a reliable diagnostic marker.
- Additionally, miR-212 was found to inhibit the expression of genes linked to cell proliferation and survival in gastric cancer cells, suggesting its involvement in cancer progression and prognosis.
Background: Castleman disease (CD) is a rare lymphoproliferative disease characterized by high heterogeneity in clinical manifestation and prognosis. This study aimed to summarize clinical features of localized retroperitoneal CD and our experiences to improve the diagnosis and treatment of this disease.
Methods: Clinical data of 45 patients with localized retroperitoneal CD were retrospectively analyzed.
Crosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells.
Cancer Biol Ther
July 2020
TF/FVIIa (Tissue Factor/Active Coagulation factor VII) and EGFR (Epidermal Growth Factor Receptor) signaling both promote malignant progression of colorectal cancer. However, the crosstalk of these two signaling pathways in human colorectal cancer cells remains unclear. Here we detected the changes of mRNA profile in human colorectal cancer cell SW620 exposed to FVIIa.
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