Slit2-Robo4 signal pathway and tight junction in intestine mediate LPS-induced inflammation in mice.

Background: Sepsis is one of the most common clinical diseases, which is characterized by a serious and uncontrollable inflammatory response. LPS-induced inflammation is a critical pathological event in sepsis, but the underlying mechanism has not yet been fully elucidated.

Methods: The animal model was established for two batches.