Cost-effectiveness analysis of the integrated control strategy for schistosomiasis japonica in a lake region of China: a case study.

Background: Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and long-term sequelae. An integrated control strategy implemented in the Peoples' Republic of China has been shown to be effective to control or interrupt the transmission of schistosomiasis. The objective of this study is to estimate the disease burden of schistosomiasis and assess the cost-effectiveness of the integrated control strategy focused on different major interventions at three stages for schistosomiasis control in a lake setting, to provide reference for policy making or planning.

[Survey of knowledge and practice of residents about schistosomiasis prevention and control in endemic areas of Jingzhou City].

Objective: To investigate the knowledge and practice of residents about schistosomiasis prevention and control in endemic areas of Jingzhou City, Hubei Province after the disease transmission being controlled, so as to provide the valuable information for formulating an efficient health education and intervention strategy.

Methods: The residents were selected by using the cluster sampling method and investigated with questionnaires in Jiangling County and Gong'an County, Jingzhou City, Hubei Province, and the data were analyzed by using the descriptive analysis method, Chi-square tests and logistic regression.

Results: In a total, 826 available questionnaires were obtained with 100% of valid rate.

[Changes of serum anti-schistosome antibody levels in schistosomiasis japonica patients after treatment].

Objective: To investigate the changes of serum anti-schistosome antibody titers in schistosomiasis japonica patients after treatment, in order to provide the evidence for formulating the schistosomiasis surveillance program in marshland and lake regions.

Methods: Upon prospective cohort study, the stool examination positive schistosomiasis patients and blood examination positive suspected patients (the titer was more than 1:80, including 1:80) were selected as the research objects in Jiangling County in 2014, and they received the 2-day praziquantel therapy. Half year, one year and two years after the treatment, their blood samples and fecal samples were collected for IHA anti-schistosome antibody detections and schistosome egg and miracidium detections.

[Distribution features of wild feces in schistosomiasis endemic areas in Jiangling County, Hubei Province].

Objective: To understand the spatial distribution characteristics of wild feces in schistosomiasis endemic areas of Jiangling County, Hubei Province and further explore the source of infection efficiently, so as to provide the evidence for the development of corresponding monitoring and response technology.

Methods: In 2011, the fresh wild feces were investigated every two months in the selected 15 villages by the severity of historical endemic in Jiangling County. The schistosome miracidium hatching method was used to test the schistosome infection of the wild feces.

Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County, Hubei Province, P.R. China.

Background: The prevalence of schistosomiasis remains a key public health issue in China. Jiangling County in Hubei Province is a typical lake and marshland endemic area. The pattern analysis of schistosomiasis prevalence in Jiangling County is of significant importance for promoting schistosomiasis surveillance and control in the similar endemic areas.

[Pattern analysis of tempo-spatial distribution of schistosomiasis in marshland epidemic areas in stage of transmission control].

Objective: To investigate the tempo-spatial patterns of schistosomiasis in Jiangling County, Hubei Province, so as to identify the risk areas and provide the scientific evidence in following intervention plans for marshland epidemic areas in the stage of transmission control.

Methods: The schistosomiasis epidemiological data in Jiangling County from 2009 to 2013 together with the related geographical information were collected and analyzed. The tempo-spatial distribution patterns were analyzed by the spatial autocorrelation analysis and spatial clustering analysis.

[Effect of two-level community-based health education pattern on schistosomiasis control].

Objective: To implement a two-level community-based health education pattern of schistosomiasis in residents of endemic areas in marshland and lake regions, so as to explore the suitable pattern of health education under hypo-endemic situation.

Methods: Two schistosomiasis endemic villages in Jiangling County, Hubei Province were collected as study areas, and among which, one village was treated as an intervention group, where the two-level community-based health education pattern as well as regular control measures was implemented; the other village was a control group, where only regular control measures were implemented. The awareness rates on schistosomiasis control, the rates of correct behavior and the compliance rates of examination, treatment and chemotherapy of the two groups before and after the intervention were compared.

[ snail control effects of molluscicides with different formulations in field in marshland and lake regions].

Objective: To observe the snail control effects of molluscicides with different formulations in the ditch with unstable water level in field of marshland and lake areas, so as to provide the evidence for formulating the prevention strategies.

Methods: A drainage channel with snails in Jiangling County, Jingzhou City were selected as the study field, then it was divided into 6 segments, except 1 segment was treated as the blank control group for observing the natural mortality rate of the snails, the other 5 segments were treated as observation groups, where 4% niclosamide ethanolamine salt powder, 5% niclosamide ethanolamine salt granule, 25% suspension concentrate of niclosamide ethanolamine salt, 26% suspension concentrate of metaldehyde and niclosamide ethanolamine salt, 50% niclosamide ethanolamine salt wettable powder were applied respectively. Before and after the mollusciciding, the snail surveys were carried out through the systematic sampling method, and the short- and long-term effects of snail control were observed, and the mortality rates of the snails on the slope above the water level and those below the water level were compared.

[Cost-effectiveness evaluation on comprehensive control measures carrying out in schistosomiasis endemic areas with regard to different layers of administrative villages stratified by infection situation of human and domestic animals. II Correlation analysis of costs and inputs with changes of schistosomiasis endemic situation in inner embankment of marshland and lake regions from 2006 to 2013].

Objective: To investigate the correlations between inputs and costs and endemic situation of schistosomiasis in inner embankment, so as tb provide the references for the strategy optimization of schistosomiasis control.

Methods: Jiangling County was selected as the study field. The correlatibn and regression analyses were applied to analyze the endemic situation of schistosomiasis in Jiangling County from 2006 to 2013.

[Analysis of schistosomiasis endemic situation in Jiangling County from 2004 to 2013].

Objective: To analyze the schistosomiasis endemic situation and understand its transmission trend in Jiangling County from 2004 to 2013, so as to improving the schistosomiasis control.

Methods: The relevant data of schistosomiasis were collected and analyzed statistically in Jiangling county from 2004-2013.

Results: The human prevalence of schistosomiasis was decreased from 10.

[Efficacy of routinely used patterns for schistosomiasis diagnosis in lake and marshland regions].

Objective: To evaluate the efficacy of routinely used pattern for schistosomiasis diagnosis in lake and marshland regions.

Methods: A historically heavy endemic village of schistosomiasis named Jinggan Village from Jiangling County was selected for field survey. The residents aged 6-65 years were screened by indirect hemagglutination assay (IHA) and dipstick dye immunoassay (DDIA) in parallel.

[Construction and operation of network laboratory for schistosomiasis diagnosis in Jianglin County].

Objective: To build a high quality diagnosis system for schistosomiasis surveillance in the situation of low infection in Jianglin County.

Methods: The network laboratory for schistosomiasis diagnosis was built according to the national criteria in Jianglin County in 2012.

Results: The network laboratory for schistosomiasis diagnosis was established successfully and the operation was quiet well.