Publications by authors named "He-Guan Fu"
Objective: Diabetes is often linked to poorer outcomes in patients with moyamoya disease (MMD). However, experience has shown that certain individuals with diabetes have favorable outcomes after encephaloduroarteriosynangiosis (EDAS). The authors aimed to develop a nomogram to predict good neoangiogenesis in patients with MMD and type 2 diabetes mellitus (T2DM) to aid neurosurgeons in the identification of suitable candidates for EDAS.
View Article and Find Full Text PDFObjective: The aim of this study was to develop and validate a predictive nomogram model for long-term rebleeding events in patients with hemorrhagic moyamoya disease (HMMD).
Methods: In total, 554 patients with HMMD from the Fifth Medical Center of the Chinese PLA General Hospital (5-PLAGH cohort) were included and randomly divided into training (390 patients) and internal validation (164 patients) sets. An independent cohort from the First Medical Center and Eighth Medical Center of Chinese PLA General Hospital (the 1-PLAGH and 8-PLAGH cohort) was used for external validation (133 patients).
Article Synopsis
- - The study investigates the role of the immune system, specifically complements and immunoglobulin levels, in the progression of moyamoya disease (MMD) by comparing serum samples from 84 MMD patients and 70 healthy individuals.
- - Results indicate that MMD patients have lower serum levels of complement C3, particularly those in late-stage disease, and identified age, diastolic blood pressure, and complement C3 as significant factors associated with the progression of vasculopathy.
- - The findings suggest that complement C3 levels could be linked to the advancement of MMD, highlighting its potential role in the disease's development and progression.
Isolated anterior cerebral artery occlusion: an atypical form of moyamoya disease.
Stroke Vasc Neurol
December 2024
Background: The relationship between anterior cerebral artery (ACA) occlusion and moyamoya disease (MMD) has rarely been studied. In this study, we focused on a special type of MMD: isolated ACA-occlusive MMD. We investigated clinical attributes, genotypes and progression risk factors in patients with ACA-occlusive MMD, providing initial insights into the relationship between ACA occlusion and MMD.
View Article and Find Full Text PDFObjective: This study aimed to explore the long-term outcome of unilateral moyamoya disease and predict the clinical and genetic factors associated with contralateral progression in unilateral moyamoya disease.
Methods: We retrospectively recruited unilateral moyamoya disease patients with available genetic data who underwent encephaloduroarteriosynangiosis (EDAS) surgery at our institution from January 2009 to November 2017. Long-term follow-up data, including clinical outcomes, angiographic features, and genetic information, were analyzed.
Objective: This study aimed to explore the clinical features of moyamoya disease (MMD) and the efficacy of encephaloduroarteriosynangiosis (EDAS) in elderly patients with MMD and to identify the risk factors for long-term stroke events.
Methods: Clinical data were retrospectively collected on elderly patients with MMD (age ≥ 60 years) who had been treated at the authors' center from May 2007 to December 2017. Clinical features, angiographic findings, and long-term outcomes (> 5-year follow-up) were analyzed.
Article Synopsis
- The study investigated the course and risk factors of moyamoya disease (MMD) in patients with unruptured intracranial aneurysms from 2006 to 2021.
- It analyzed 42 patients, mainly adults, noting symptoms like cerebral ischemia and hemorrhage, and found that most aneurysms were small and did not rupture during follow-up.
- Results indicated a low risk of aneurysm rupture since many either stayed the same or shrank, suggesting that direct intervention may not be needed for aneurysms when associated with stenosed parent arteries.
Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke.
J Cereb Blood Flow Metab
April 2023
The influence of hypoperfusion on cognition in patients with Moyamoya disease (MMD) is unclear. This study investigated cognitive function changes in MMD patients without stroke and illustrated the relationship between cognitive impairment and hypoperfusion. We prospectively performed a structured battery of seven neurocognitive tests on 115 adult MMD patients without stroke and 82 healthy controls.
View Article and Find Full Text PDFBackground: Spontaneous low-frequency oscillations (LFOs) have been widely studied in cerebrovascular disease, but little is known about their role in moyamoya disease (MMD). The objective of this study was to assess the value of spontaneous LFOs in MMD based on wavelet analysis of near-infrared spectroscopy signals.
Methods: Sixty-four consecutive idiopathic adult patients were prospectively enrolled.