A survey on perioperative antibiotic use for minimally invasive coronary artery bypass grafting.

Objective: To investigate the use of antimicrobials during the perioperative period of minimally invasive coronary artery bypass grafting (MICS CABG) and traditional open-heart bypass grafting. We aimed to determine whether the duration of perioperative antibiotic use and infection rate is significantly different between different surgical methods.

Methods: A total of 471 cases of coronary artery bypass grafting (CABG) were collected from January 2019 to December 2022.

Roles of macrophages in lupus nephritis.

LN is a serious complication of systemic lupus erythematosus (SLE), affecting up to 60% of patients with SLE and may lead to end-stage renal disease (ESRD). Macrophages play multifaceted roles in the pathogenesis of LN, including clearance of immune complexes, antigen presentation, regulation of inflammation, and tissue repair. Macrophages are abundant in the glomeruli and tubulointerstitium of LN patients and are positively correlated with serum creatinine levels and the severity of renal pathology.

Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway.

DNA damage resulting from UV irradiation on the skin has been extensively documented in numerous studies. In our prior investigations, we demonstrated that UVB-induced DNA breakage from keratinocytes can activate the cGAS-STING pathway in macrophages. The cGAS-STING signaling pathway serves as the principal effector for detecting and responding to abnormal double-stranded DNA in the cytoplasm.

Histone deacetylase 9 plays a role in sevoflurane-induced neuronal differentiation inhibition by inactivating cAMP-response element binding protein transcription and inhibiting the expression of neurotrophin-3.

Postoperative cognitive decline (POCD) is a common and serious complication following anesthesia and surgery; however, the precise mechanisms of POCD remain unclear. Our previous research showed that sevoflurane impairs adult hippocampal neurogenesis (AHN) and thus cognitive function in the aged brain by affecting neurotrophin-3 (NT-3) expression; however, the signaling mechanism involved remains unexplored. In this study, we found a dramatic decrease in the proportion of differentiated neurons with increasing concentrations of sevoflurane, and the inhibition of neural stem cell differentiation was partially reversed after the administration of exogenous NT-3.

PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that promotes the degradation of low-density lipoprotein receptors. It is involved in hyperlipidemia as well as other diseases, such as cancer and skin inflammation. However, the detailed mechanism for PCSK9 on ultraviolet B (UVB)-induced skin lesions was not clear.

Combination of apatinib with apo-IDO1 inhibitor for the treatment of colorectal cancer.

Colorectal cancer (CRC) is the third most common cancer in the world. Recently, many clinical studies have demonstrated the therapeutic potential of immune checkpoint therapy combined with inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) in colon cancer. Compound B37, identified in our previous experiment, is an apo-form indoleamine-2,3-dioxygenase 1 inhibitor (apo-IDO1 inhibitor), which has been shown to significantly suppress tumor growth combined with an anti-PD1 antibody.

White-Cell Derived Inflammatory Biomarkers in Prediction of Postoperative Delirium in Elderly Patients Undergoing Surgery for Lower Limb Fracture Under Non-General Anaesthesia.

Purpose: The aim of this study was to investigate whether white-cell derived biomarkers could serve as potential markers in prediction of postoperative delirium (POD) after lower limb fracture.

Patients And Methods: Elderly patients with surgery for lower limb fracture under non-general anaesthesia were included. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet-to-white cell ratio (PWR), which were most recently measured preceding surgery and measured within 24h after surgery, were calculated.

Effect of strontium on nutrient uptake, physiological parameters, and strontium localization in lettuce.

Human activities increase the risk of stable and radioactive strontium (Sr) isotopes entering the environment and food chain. In this study, the effects of Sr on the nutrient uptake and physiological responses of lettuce under different "Sr treatment" concentrations (0, control, 1, 2, 3, 4, and 5 mM) and "times" (7, 14, and 21 day) were studied in a hydroponic system. In addition, the distribution of Sr on the surfaces and cross-sections of lettuce leaves was revealed by scanning electron microscopy with energy-dispersive X-ray (SEM-EDX) analysis.

Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis.

Inflammatory bowel disease (IBD) is a worldwide prototypical complex disease, owing to its multifactorial causes, relapsing and remitting condition and high incidence. Thus, effective therapeutic approaches need to be developed for patients with IBD. Currently, we reported the improving effect of magnesium isoglycyrrhizinate on colitis induced by dextran sulfate sodium (DSS).

Strontium Uptake and Effect in Lettuce and Radish Cultivated Under Hydroponic Conditions.

The accumulation of strontium (Sr) in lettuce and radish under 0 (control), 0.5, 1, 2.5, 5, and 10 mM Sr treatments in hydroponic solution at 16, 23 and 30 days and the effects of Sr stress on six nutrient elements in plants were investigated.

Effects of particles on potential denitrification in the coastal waters of the Beibu Gulf in China.

Although the influence of suspended particulate matter (SPM) on denitrifying activity has been identified in river waters recently through metabolic incubations and community gene analysis, the regulations of SPM to denitrification in marine systems are still poorly understood. In the present study, the effects of suspended particle properties (including concentration, composition and size) on potential denitrification were explored in the coastal Beibu Gulf water columns based on a series of N-labeled incubations under artificial anaerobic condition. A gradient of oxygen (O) concentrations was also manipulated in the incubated seawaters to test the sensitivity of denitrification to O exposure.

[Development and inheritance of 's acupuncture school].

's acupuncture school in Gansu,represented by and ,is of great influence in China. 's acupuncture school originated from (Inner Canon of Yellow Emperor) and (Classic of Questioning),and shaped around Dynasty and Dynasty. Professor has formed a unique "'s acupuncture" diagnosis and treatment system by inheritance and innovation.

Simulating the Transfer of Strontium-90 from Soil to Leafy Vegetables by Using Strontium-88.

The transfer, from soil to Chinese cabbage and spinach, of radioactive strontium-90 released as a result of accidents in nuclear power stations was studied using a stable isotope of strontium, namely nuclide strontium-88 (Sr). The study led to an experimental model for assessing the hazard of radionuclide strontium-90 (Sr) entering the food chain and for predicting the risk to food safety. Chinese cabbage and spinach were grown in pots in a greenhouse and irrigated with deionized water containing known quantities of strontium.