Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors.

Ferroptosis is a novel form of regulated cell death characterized by iron-dependent lipid ROS accumulation, which is associated with various diseases, including acute organ injury, neurodegenerative disorders, and cancer. Pharmacological inhibition of ferroptosis has great potential for the treatment of these diseases. However, the clinical translation of many ferroptosis inhibitors is hindered by their inadequate activity or suboptimal pharmacokinetic profiles.

Gliadin/Konjac glucomannan particle-stabilized Pickering emulsion for honokiol encapsulation with enhanced digestion benefits.

Owing to the limited availability of biocompatible, edible and natural emulsifiers, the development of Pickering emulsions applicable to the food industry still confronts challenges. Moreover, Honokiol (HNK), due to its poor stability and susceptibility to oxidation, most of the existing delivery systems are centered on injection administration routes and relatively complex in preparation, posing significant challenges for industrialization. In this research, a Pickering emulsion system stabilized by gliadin and konjac glucomannan composite particles (GKPs) was constructed using the pH cycling method and was employed for the delivery of HNK.

Self-cleaning micro/nano graded porous groove structure fiber membranes by coaxial spinning for purification of dye wastewater.

Adjusting the structure of the membrane and improving its performance proved to be an effective technique for accomplishing efficient dye wastewater purification. Water erosion of polyvinylpyrrolidone (PVP) core in polyacrylonitrile (PAN) nanofiber membrane modified with UiO-66-NH was successfully achieved, in this study, using coaxial electrospinning, and ZIF-8 with excellent performance was further epitaxy-grown in situ. Two differently shaped and positively charged MOFs confer strong adsorption capacity (adsorption capacity >2042 mg/g) on cationic dyes.

Cardiac compressed sensing real-time cine for the assessment of left ventricular function: a large sample size analysis.

Background: Segmented cine imaging using a balanced steady-state free precession sequence is the gold standard for accurately quantifying cardiac function and myocardial mass. However, this method suffers from inefficient K-space sampling, resulting in long scan times, and requires multiple breath holds that can be difficult for some patients. Real-time compressed sensing (CS) cine reduces image acquisition time through K-space undersampling and iterative reconstruction, enabling rapid magnetic resonance (MR) imaging.

Alleviates Hyperoxia-Induced BPD by Activating IL-22/STAT3 Signaling Pathway in Neonatal Mice.

Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little is known about the regulatory effect of lung and its mechanism in BPD. This study explored the effect of on hyperoxia-induced mice lung injuries and examined whether played a role via the IL-22/STAT3 pathway.

Preparation and performance evaluation of an efficient microbial dust suppressant for dust control in disturbed areas of blast piles in open-pit coal mines.

Open-pit coal mining creates large rock piles as a result of removing overlying strata. When disturbed by loading operations and wind, these rock piles release considerable dust, leading to significant environmental pollution. This study aims to develop an environmentally friendly and cost-effective method for dust control in disturbed areas of open-pit coal mines, using Sporosarcina pasteurii as a microbial dust suppressant to explore its potential application and development.

Oxidation of CaMKIIα cysteines inhibits autonomous activation induced by phosphorylation.

Ca/calmodulin-dependent protein kinase II α (CaMKIIα) "autonomous" activation induced by Thr286 phosphorylation has a crucial role in synaptic plasticity. Previous studies showed that in Alzheimer's disease brain, CaMKIIα autophosphorylation at Thr286 is reduced while the level of cysteine-oxidized CAMKIIα is elevated. We performed tryptic mapping of the oxidized CaMKIIα and discovered the formation of a disulfide between the N-terminal Cys6 and the regulatory domain Cys280.

Urethra-preserving and dorsal capsule fenestration with robot-assisted simple prostatectomy for severe LUTS in small prostate: a case report.

Background: Small prostates (volume <30 ml) induce bladder outlet obstruction with pathophysiological changes distinct from those associated with large prostates. Treatment options often include transurethral incision of the prostate (TUIP) or transurethral resection of the prostate (TURP). Existing treatments have issues with high recurrence and complication rates.

Transcriptomic Alterations in the Hippocampus and Prefrontal Cortex of Rats with Chronic Unpredictable Stress Induced by Low-Intensity Pulsed Ultrasound.

In our previous study, low-intensity pulsed ultrasound stimulation (LIPUS), a novel noninvasive neuromodulation tool, effectively alleviated depression-like behaviors in a rat model of depression. However, the underlying mechanisms remain unclear. The present study aimed to elucidate the relevant mechanisms through transcriptomic research.

The genus Phanagenia Banks, 1933 (Hymenoptera: Pompilidae) from China with descriptions of two new species and a key to the world species.

The genus Phanagenia Banks, 1933 from China is reviewed. Two new species, Phanagenia bidenticulata He & Ma, sp. nov.

Enrichment of carcinoembryonic antigen by epitope molecularly imprinted polymer based on cucurbituril host-guest interaction.

Carcinoembryonic antigen (CEA) is a common tumor marker used to diagnose diseases. However, the use of molecularly imprinted polymer with whole proteins as templates or antibodies to identify and isolate CEA presents issues such as high prices and difficult removal of templates. Here, due to the specific binding of cucurbit[7]uril (CB[7]) to N-terminal phenylalanine, we prepared a novel oriented epitope molecularly imprinting polymer based on host-guest interaction (hg-MIP) for the identification and separation of CEA.

[Comprehensive Eutrophication Evaluation and Water Environment Capacity Analysis of Yiwu Yankou Reservoir].

The accumulation of excessive nitrogen, phosphorus, and other nutrients in rivers, lakes, and reservoirs has greatly accelerated eutrophication, which has led to the frequent outbreaks of algal blooms and brought great ecological risks to the related aquatic ecosystems. Evaluations on the eutrophic status of water bodies and estimations of water environment capacity are not only crucial for comprehensive assessment of eutrophic status but also indispensable references for comprehensive management of the aquatic ecosystems. In this study, major environmental variables （chemical oxygen demand, total nitrogen, and total phosphorus） of Yankou Reservoir watershed were monitored monthly from May 2020 to March 2022 and based upon the determined results, the comprehensive eutrophic conditions and water environment capacity were evaluated and estimated.

Analysis of Sulfate Compounds From Sanguisorbae Radix and Its Major Metabolites in Rats by UPLC-MS/MS and Molecular Docking.

Rationale: Sanguisorbae Radix that mainly contains tannins and phenolic compounds has been widely used as a traditional Chinese medicine for treating hemafecia, hemorrhoids metrorrhagia and metrostaxis in clinics. However, there is no report about the sulfate phenolic compounds in Sanguisorbae Radix.

Methods: Extraction of Sanguisorbae Radix was separated and purified by polyamide resin and octadecyl silane-bonded silica, which were analyzed by HPLC-IT-TOF/MS.

The impact of cerebral small vessel disease burden on prognosis in patients with acute coronary syndrome.

Background: Acute coronary syndrome (ACS) presents with a variable prognosis, posing significant public health challenges. This study investigated the potential link between cerebral small vessel disease (CSVD) burden and outcomes in patients with ACS.

Methods: In this retrospective cohort study, ACS patients admitted to Beijing Friendship Hospital, Capital Medical University, Beijing, China from January 2020 to October 2021, were analyzed.

Kinetic modeling of sulfonamide degradation by UV/HO: Deduction of R modeling and application.

Eight sulfonamide (SA) antibiotics were effectively degraded using a UV/HO process in a quasi-collimated beam apparatus, utilizing optimized fluence quantification. Fluence-based rate constants (kk') for the UV/HO process were established. A curve-fitting method, derived from R modeling, was developed for the UV/HO process to quantitatively assess the impact of critical factors, including water quality and direct UV photolysis.

Development and validation of the prediction model based on autophagy-associated genes in bronchopulmonary dysplasia.

Background: Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease among preterm infants. Owing to the limitations in current diagnostic methods, developing a predictive model for BPD is crucial.

Methods: Using 243 autophagy-associated genes and dataset GSE32472, differential expression of autophagy-associated genes was identified at postnatal days 5, 14, and 28 between BPD patients and controls.

The mediating role of remnant cholesterol in the associations of Angiopoietin-like 8 with all-cause, CVD, and cancer death: the China Cardiometabolic Disease and Cancer Cohort (4C) study.

Purpose: To investigate the potential mediating effect of remnant cholesterol (RC) in the associations between angiopoietin-like 8 (ANGPTL8) and the risk of all-cause, cardiovascular disease (CVD), and cancer death.

Methods: This prospective observational study included 3278 individuals from China. Binary logistic regression and mediation analyses were conducted to investigate the mediating effect of RC in the associations between ANGPTL8 and all-cause, CVD, and cancer death.

Impact of endogenous viral elements on glioma clinical phenotypes by inducing OCT4 in the host.

Introduction: Endogenous viral elements (EVEs) are viral sequences integrated within the host genome that can influence gene regulation and tumor development. While EVEs have been implicated in cancer, their role in regulating key transcription factors in glioblastoma (GBM) remains underexplored. This study investigates the relationship between EVEs and the activation of OCT4, a critical transcription factor in GBM progression.

Unlocking the Mysteries of the Desorption-Ionization Mechanism via Separate Thermal and Charge Strategies.

Herein, a new strategy is employed to build a controllable thermal-coupled charge ionization (TCCI) device to elucidate the desorption-ionization mechanism of plasma ion sources. Efficient synergistic desorption and ionization are achieved within the TCCI device by independently controlling the desorption temperature and plasma charges. The TCCI device efficiently ionizes samples using abundant free electrons, charges, and active species from arc plasma.