Combining Ti(embonate) anionic cages and π-conjugated coordination cations for highly effective optical limiting.

The integration of anionic TiL (L = embonate) cages and π-conjugated coordination cations into ordered structures can produce high-performance nonlinear optical (NLO) materials. More specifically, by employing TiL cages for assembly with mixed ,-chelated and ,-chelated type conjugated organic ligands and Ag ions, three cage-based structures have been synthesized and structurally characterized. Among them, an ion pair structure with strong π-π accumulation exhibits a significant third-order NLO response, and an excellent optical limiting effect has been experimentally verified.

Integrated Anionic Zirconium-Organic Cage and Cationic Boron-Imidazolate Cage for Synergetic Optical Limiting.

Making oppositely charged metal-organic cages (MOCs) into a tightly ordered structure may bring interesting functions. Herein, we report a novel structure composed of anionic (Zr L ) (L=embonate) tetrahedral cages and in situ-formed cationic [Zn (Bim) ] (Bim=[BH(im) ] ; im=imidazole) cubic cages. Chiral transfer is observed from enantiopure (Zr L ) cage to enantiopure [Zn (Bim) ] cage.

Enhancing Third-Order Nonlinear Optical Property by Regulating Interaction between Zr(embonate) Cage and N, N-Chelated Transition-Metal Cation.

Herein, the combination of anionic ZrL (L = embonate) cages and N, N-chelated transition-metal cations leads to a series of new cage-based architectures, including ion pair structures ( and ), dimer (), and 3D frameworks ( and ). Structural analyses show that exhibits a 2-fold interpenetrating framework with a 3,4-connected topology, and shows a 2-fold interpenetrating framework with a 4-connected network. Both and can be stable in air and other common solvents at room temperature.

Post-Assembly Modification of Homochiral Titanium-Organic Cages for Recognition and Separation of Molecular Isomers.

A chiral metal-organic cage (MOC) was extended and fixed into a porous framework using a post-assembly modification strategy, which made it easier to study the host-guest chemistry of the solid-state MOC using a single-crystal diffraction technique. Anionic Ti L (L=embonate) cage can be used as a 4-connecting crystal engineering tecton, and its optical resolution was achieved, thus homochiral ΔΔΔΔ- and ΛΛΛΛ-[Ti L ] cages were obtained. Accordingly, a pair of homochiral cage-based microporous frameworks (PTC-236(Δ) and PTC-236(Λ)) were easily prepared by a post-assembly reaction.

Synthesis and anti-HIV activity of non-nucleoside reverse-transcriptase inhibitor DB02 phosphate derivatives based on water-soluble optimization.

To improve the water solubility of anti-human immunodeficiency virus (HIV) agent DB02, an excellent non-nucleoside reverse-transcriptase inhibitor (NNRTI) obtained in our previous efforts, we designed and synthesized four phosphate derivatives of DB02 based on the molecular model of DB02 with RT. Here, the antiviral activity of these four derivatives was detected, leading to the discovery of compound P-2, which possessed a superior potency to the lead compound DB02 against wild-type HIV-1 and a variety of HIV-resistant mutant viruses significantly. Furthermore, the water solubility of P-2 was nearly 17 times higher than that of DB02, and the pharmacokinetic test in rats showed that P-2 demonstrate significantly improved oral bioavailablity of 14.

Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase.

Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome. Although many efforts have been made to combat ZIKV infection, there is currently no approved vaccines or antiviral drugs available and there is an urgent need to develop effective anti-ZIKV agents. In this study, 26 acetylarylamine--DACOs derivatives were prepared, and eight of them were found to have inhibitory activity against Zika virus.

Synthesis of a Zr(embonate)-cobalt based superstructure for photocatalytic hydrogen production.

Herein, we report an efficient method to construct cage-based MOF materials with exposed metal active sites for catalysis. By employing ZrL (L = embonate) cages as precursors for assembly with N-containing ligands and Co ions, a new ZrL-Co based chain structure (PTC-318) has been generated through two-step reactions. Interestingly, in the absence of a photosensitizer, PTC-318 exhibits notable photocatalytic activity for H evolution under visible-light irradiation.

C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity.

Both HIV and DENV are serious threats to human life, health and social economy today. So far, no vaccine for either HIV or DENV has been developed successfully. The research on anti-HIV or DENV drugs is still of great significance.

Coordination Assembly of Tetrahedral Zr(embonate) Cages with Eu Ions.

Herein we systematically investigated the coordination assembly behavior of ZrL cages with Eu ions at room temperature. Through adjustment of the concentration of Eu salt and changes of the type and molar ratio of the solvent, a series of ZrL-Eu structures with different structure dimensionalities have been synthesized and structurally characterized. In addition, we also studied the optical properties of these materials in detail, including the fluorescent and third-order nonlinear-optical properties.

A green separation process of Ag a Ti(embonate) cage.

From an environmental perspective, silver recovery through a green process is imperative. In this work, a green supramolecular separation process of Ag has been developed by using a highly charged anionic Ti4L6 (L = embonate) cage as the extractant. Such a Ti4L6 cage has unique selectivity toward [Ag(NH3)2]+ ions, because only linear [Ag(NH3)2]+ ions can be trapped into the windows of the Ti4L6 cage, which is demonstrated by single-crystal X-ray diffraction analysis.

Combining a Titanium-Organic Cage and a Hydrogen-Bonded Organic Cage for Highly Effective Third-Order Nonlinear Optics.

Many metal-organic cages (MOCs) and a few hydrogen-bonded organic cages (HOCs) have been investigated, but little is reported about cooperative self-assembly of MOCs and HOCs. Herein, we describe an unprecedented MOC&HOC co-crystal composed of tetrahedral Ti L (L=embonate) cages and in-situ-generated [(NH ) (TIPA) ] (TIPA=tris(4-(1H-1,2,4-triazol-1-yl)phenyl)amine) cages. Chiral transfer is observed from the enantiopure Ti L cage to enantiopure [(NH ) (TIPA) ] cage.

Self-Assembly of a Ti(embonate) Cage toward Silver.

Herein we report a variety of supramolecular architectures that are self-assembled by the highly charged anionic TiL (L = embonate) cages and noble-metal Ag ions in the presence of the different ligands, including six TiL-Ag(PPh) cages in whose structures the TiL cage catches various in situ formed [Ag(PPh)] moieties by a coordination bond and one cocrystal superstructure of a TiL cage with an in situ generated [Ag(PhP(CH)PPh)] cage via supramolecular interactions. In addition, the third-order nonlinear-optical properties of these compounds are investigated in detail.

Identifying risk factors for chronic kidney disease stage 3 in adults with acquired solitary kidney from unilateral nephrectomy: a retrospective cohort study.

Background: We aimed to examine the risk factors for chronic kidney disease (CKD) stage 3 among adults with ASK from unilateral nephrectomy.

Methods: We retrospectively collected data from adult patients with ASK between January, 2009 and January, 2019, identified from a tertiary hospital in China. The clinical data were compared between patients who developed CKD stage 3 and those who did not develop CKD stage 3 during follow-up.

Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.

In order to discover and develop the new HIV-1 NNRTIs, a series of 5-alkyl-6-(benzo[d][1,3]dioxol-5-ylalkyl)-2-mercaptopyrimidin-4(3H)-ones was synthesized and screened for their in vitro cytotoxicity against HIV-1. Most of the compounds we synthetized showed high activity against wild-type HIV-1 strain (IIIB) while IC values are in the range of 0.06-12.

Ti(embonate) Cage-Ligand Strategy on the Construction of Metal-Organic Frameworks with High Stability and Gas Sorption Properties.

Herein we report an efficient strategy to construct cage-based metal-organic frameworks (MOFs) via the assembly of TiL (L = embonate) cages and N-contained ligands with Mn and Zn ions, respectively, and two TiL-cage-based MOFs ( and ) with high stability and gas sorption properties have been generated through two-step reactions, respectively.

Synthesis and Photoelectric Properties of Metal-Organic Zeolites Built from TO and Organotin.

Herein we report a novel strategy capable of generating a new class of metal-organic zeolite (MOZ) materials. When the MoO or WO tetrahedra are employed to assemble with triorganotin RSn fragments, four 3D networks with the zeolite BCT topology and nonzeotype 4-connected topological net (such as lon and dia) have been generated. The photocurrent study results show that these materials have good photoelectric response and high photophysical stability.

[Effect of platelet rich fibrin combining with Bio-oss to treat furcation involvement].

Purpose: To evaluate the effect of platelet rich fibrin (PRF) combining with Bio-oss in treating Class II furcation involvement.

Methods: Thirty patients who had Class Ⅱ furcation involvement in the mandibular first molar were included. They were all free of systemic disease.

Embonic Acid Functionalized Niobium Complexes with Selective Dye Sorption Properties.

Presented here are binuclear Nb, tetranuclear TiNb, and dodecanuclear Nb complexes decorated by embonic acid ligands. These structures feature a unique Ti-O-Nb or Nb-O-Nb subunit. Besides, the unprecedented dodecanuclear Nb cluster further displays a porous three-dimensional packing framework and stability in water, affording an interesting selective uptake for methylene blue molecules over rhodamine B.

Water-Soluble and Ultrastable TiL Tetrahedron with Coordination Assembly Function.

We have successfully constructed a tetrahedral TiL cage with calixarene-like coordination-active vertices. It further features high solubility and stability in HO and DMF/HO solution, affording an interesting stepwise assembly function with other metal ions. Through trapping of different amounts of Co or Ln ions, the TiL tetrahedra can be organized into various dimensional architectures, including a TiL-Co cage, a TiL-Ln cage, a TiL-Ln chain, and a three-dimensional TiL-Ln framework.

Polycatenation tuned microporosity of two metal-tris(4'-carboxybiphenyl)amine frameworks with multilayer structures.

By employing a nanosized tris(4'-carboxybiphenyl)amine ligand to assemble with Zn ions, a novel trilayer network (FIR-37) and an unprecedented 2D → 3D microporous polycatenation framework (FIR-38) based on unusual tetralayers have been synthesized and structurally characterized. FIR-38 shows permanent porosity with a Langmuir surface area of 1408.4 m g.

Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.

Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced by oxygen and glucose deprivation (OGD) in neonatal rat primary-cultured hippocampal neurons and its mechanisms were investigated. Cultured hippocampal neurons, which were exposed to OGD for 2 h followed by a 24 h reoxygenation, were used as an in vitro model of ischemia and reperfusion.

[Expressions of EMMPRIN and its ligand CyPA in gingival crevicular fluid of chronic periodontitis patients].

Purpose: To detect the expressions of EMMPRIN and its ligand CyPA in gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients and explore their possible relation to the status of periodontal inflammation.

Methods: GCF of CP patients (group CP) and periodontitis-free patients with intact dentition (the control group) were collected and assayed for EMMPRIN and CyPA expressions by ELISA. The clinical periodontal status of these patients were examined.

Gas Sorption, Second-Order Nonlinear Optics, and Luminescence Properties of a Multifunctional srs-Type Metal-Organic Framework Built by Tris(4-carboxylphenylduryl)amine.

A chiral 8-fold interpenetrating srs-type metal-organic framework FIR-28 (FIR denotes Fujian Institute of Research) exhibits a surface area of 1029 m(2)/g and high C3H8/CH4 separation capacity in excess of 154 and displays strong powder second-harmonic-generation efficiency, with more than half over potassium dihydrogen phosphate powder. Moreover, the luminescence properties of FIR-28 are dependent on the solvent guests.

[Problems in quality standard research of new traditional Chinese medicine compound].

The new traditional Chinese medicine compound is the main part of the research of new drug of traditional Chinese medicine (TCM), and the new Chinese herbal compound reflects the characteristics of TCM theory. The new traditional Chinese medicine compound quality standard research is one of the main content of pharmaceutical research, and is also the focus of the new medicine pharmaceutical evaluation content. Although in recent years the research level of new traditional Chinese medicine compound has been greatly improved, but the author during the review found still some common problems existing in new traditional Chinese medicine compound quality standard research data, this paper analyzed the current quality standards for new traditional Chinese medicine compound and the problems existing in the research data, respectively from measurement of the content of index selection, determine the scope of the content, and the quality standard design concept, the paper expounds developers need to concern.