Assessment of blood-brain barrier injury in hypertensive CSVD by 11.7TMR T1mapping and microvascular pathologic changes.

We used spontaneously hypertensive rats (SHR) as a hypertensive cerebral small vessel disease (CSVD) model to quantify blood-brain barrier (BBB) disruption by 11.7TMR T1mapping and to investigate white matter lesions and microangiopathy in CSVD. Male SHR were used as a hypertensive CSVD animal model and normotensive Wistar-Kyoto rats (WKY) were used as a control model.

Localized COUP-TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts.

Decellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. Recent advances in vascular biology highlight the pivotal role of COUP-TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification.

Triptolide attenuates LPS-induced chondrocyte inflammation by inhibiting inflammasome activation via the Wnt/β-catenin and NF-κB signaling pathways.

Osteoarthritis (OA) is a common form of arthritis characterized by subchondral bone proliferation and articular cartilage degeneration. Recently, the Nod-like receptor pyrin domain 3 (NLRP3) inflammasome has gained attention due to its association with synovial inflammation in OA. Triptolide (TP), known for its immunosuppressive and anti-inflammatory effects, has been studied in various diseases.

An Efficient Biosynthetic System for Developing Functional Silk Fibroin-Based Biomaterials.

Long historical evolution and domestication endow silkworms with the super ability to synthesize and secrete massive silk proteins using silk glands. The major component of this secretion consists of silk fibroin, considered a promising biomaterial for tissue repairs and engineering. To further expand the utility of this unique protein, there is a continuing need for silk fibroin functionalization.

Quantitative proteomic landscape of the pathophysiology of adhesive arachnoiditis and its clinical significance: Structure and mechanism of TNC and RANBP1 proteins.

The pathophysiological mechanism of adhesive arachnoiditis (AA) is complex, involving the interaction of multiple proteins. In recent years, the development of quantitative proteomics technology has provided a new perspective to reveal its pathological mechanism. The main objective of this study was to reveal the changes of protein expression profiles in arachnoid tissue of patients with AA.

The effect of incline walking on lower extremity and trunk mechanics in older adults.

Older adults are at an increased risk of developing knee osteoarthritis. High internal knee abduction moment during daily activities may elevate the risk of knee osteoarthritis. Incline walking exercise has been found to decrease knee abduction moment in healthy young adults.

Decoding historical and emerging environmental concerns of C chlorinated paraffins: Insights from marine sediment cores in the Pearl River Estuary.

Chlorinated paraffins (CPs) readily deposit in sediments upon entering estuaries and adjacent seas. Time-series investigations are indispensable for the long-term monitoring of historical releases and identifying CPs of emerging concerns in the marine environment. In this study, short-, medium-, and long-chain CPs (SCCPs, MCCPs, and LCCPs) were investigated using time-of-flight high-resolution mass spectrometry (ToF-HRMS) in sediment cores, dated between the 1920s and the 2010s sampled from Hong Kong waters and Lingdingyang of the Pearl River Estuary (PRE), South China.

The miR172a-SNB module orchestrates induced and adult resistance to multiple diseases via MYB30-mediated lignin accumulation in rice.

Plants mount induced resistance and adult plant resistance against different pathogens during the whole growth period. Rice production faces threats from multiple major diseases, including rice blast, sheath blight, and bacterial leaf blight. Here we report that a microRNA module, miR172a-SNB-MYB30, regulates induced resistance and adult plant resistance to these three major diseases via lignification in rice.

The association between chronotype and social anxiety among Chinese university students: a moderated mediation analysis of loneliness and perceived social support.

Background: Social anxiety has been a burning problem among contemporary college students in China. Increasing evidence suggests that individual circadian typology-chronotype may play an important role in the development of social anxiety. However, little research has focused directly on examining the association between chronotype and social anxiety, and less is known about the mediating and moderating mechanisms underlying this relationship.

A hypoxia-activated and microenvironment-remodeling nanoplatform for multifunctional imaging and potentiated immunotherapy of cancer.

Activatable theranostic systems combining precise diagnosis and robust immune activation have significant potential in cancer treatment. Herein, we develop a versatile nanoplatform integrating hypoxia-activatable molecular imaging with effective photoimmunotherapy for cancer treatment. Our molecular probe features turn-on near-infrared-II (NIR-II) fluorescence and photoacoustic signals in hypoxic tumor environments.

Analysis and Prediction of Nonlinear Hysteretic Behaviors of Graphite Magnetorheological Grease at Different Temperatures.

Magnetorheological grease (MRG) is considered a promising alternative to magnetorheological fluids as a smart material because of its higher stability and less leakage. To enhance yield stresses in various applications, graphite is incorporated as an additive, resulting in graphite magnetorheological grease (GMRG). However, the nonlinear hysteresis properties of this new material and its prediction methods have not been investigated.

Vaping and tumor metastasis: current insights and progress.

Tumor metastasis is the primary cause of cancer-related mortality and remains a major hurdle in cancer treatment. Traditional cigarette smoking has been extensively studied for its role in promoting metastasis. However, the impact of e-cigarette (e-cig) on cancer metastasis is not well understood despite their increasing popularity as a supposedly safer alternative.

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with depressive symptoms: recent findings from NHANES 2005-2018.

Background: The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) index is a relatively new composite lipid index, the relationship between NHHR and depression is unclear from the current study. The primary aim of our study was to examine the association between the prevalence of depression and NHHR in a US population.

Methods: The National Health and Nutrition Examination Survey (NHANES) provided the data for our investigation from 2005 to 2018.

The early decline in platelet count is associated with increased adverse outcomes in non heparin-induced thrombocytopenia pediatric patients undergoing VA-ECMO.

Introduction: The impact of non heparin-induced thrombocytopenia on the clinical outcomes for pediatric cardiac surgery patients who required veno-arterial extracorporeal membrane support (VA-ECMO) for failure to wean from cardiopulmonary bypass (CPB) is uncertain. This study aimed to investigate the relationship between thrombocytopenia and prognosis in these patients.

Methods: This retrospective study enrolled 96 pediatric patients (age < 18) who received VA-ECMO directly transitioned from CPB at Fuwai Hospital from January 2010 to June 2020.

Transcriptional signatures of gray matter volume changes in mild traumatic brain injury.

Background: Neuroimaging studies have shown that patients with mild traumatic brain injury (mTBI) often exhibit changes in gray matter volume (GMV) in the brain. However, the results regarding these changes are inconsistent, and the underlying molecular mechanisms remain unclear. This study aimed to investigate GMV changes in mTBI patients and uncover the molecular mechanisms driving these alterations.

Measurement of ureteral length: Comparison of deep learning-based method and other estimation methods on CT and KUB.

Background: Accurate preoperative assessment of ureteral length is crucial for effective ureteral stenting.

Purpose: Utilize a deep learning approach to measure ureter length on CT urography (CTU) images and compare the obtained results with those derived from other estimation methods.

Methods: In a retrospective cohort (cohort A, n = 411), CTU images were collected and used to develop a 3D deep learning model for the segmentation of bilateral ureters.

Respiratory medical quality control system construction in China.

The construction of a quality control system for respiratory medicine is of great significance for improving the quality and homogenization of the diagnosis and treatment of respiratory diseases. The national respiratory quality control work conducted by the China National Respiratory Medicine Quality Control Center was summarized.

The causal relationship between anti-CD20 antibodies and endometrial cancer: a Mendelian randomization study.

Purpose: To determine the effects of anti-B cell surface marker CD20 antibody on the occurrence and progression of endometrial cancer to provide insights into clinical treatment in the future.

Methods: We performed a two-sample Mendelian randomization analysis (MR) to analyze the causal relationship between EC and immune cell markers. The genome-wide association study (GWAS) data of MS4A1 single nucleotide polymorphism encoding gene of CD20 were collected, and a drug target MR analysis was performed to detect the causal relationship between anti-CD20 antibody and the risk of EC.

Federated Learning for Predicting Postoperative Remission of Patients with Acromegaly: A Multicentered Study.

Background: Decentralized federated learning (DFL) may serve as a useful framework for machine learning (ML) tasks in multicentered studies, maximizing the use of clinical data without data sharing. We aim to propose the first workflow of DFL for ML tasks in multicentered studies, which can be as powerful as those using centralized data.

Methods: A DFL workflow was developed with 4 steps: registration, local computation, model update, and inspection.