Machine Learning-Assisted Prediction of Photothermal Metal-Phenolic Networks.

Photothermal therapy (PTT) demonstrates significant potential in cancer treatment, wound healing, and antibacterial therapy, with its efficacy largely depending on the performance of photothermal agents (PTAs). Metal-phenolic network (MPN) materials are ideal PTA candidates due to their low cost, good biocompatibility and excellent ligand-to-metal charge transfer properties. However, not all MPNs exhibit significant photothermal properties, and the vast chemical space of MPNs (over 700,000 potential combinations) complicates the screening of high-photothermal materials.

The Complete Mitochondrial Genome of the (Cypriniformes: Cyprinidae): Characterization, Phylogeny, and Genetic Diversity Analysis.

: is a species belonging to the Cyprinidae family. The objective of this study is to gain a comprehensive understanding of its evolutionary history and genetic characteristics. : The complete mitochondrial genome of .

Application of Mendelian randomization in thyroid diseases: a review.

Thyroid diseases are increasingly prevalent, posing significant challenges to patients' quality of life and placing substantial financial burdens on families and society. Despite these impacts, the underlying pathophysiology of many thyroid conditions remains poorly understood, complicating efforts in treatment, management, and prevention. Observational studies can identify associations between exposure variables and disease; however, they often struggle to account for confounding factors and reverse causation.

Three-Dimensional Printing of Bioinspired Hierarchical Structures for Enhanced Fog Collection Efficiency in 3D Space via Vat Photopolymerization.

Collecting fog water is crucial for dry areas since natural moisture and fog are significant sources of freshwater. Sustainable and energy-efficient water collection systems can take a page out of the cactus's playbook by mimicking its native fog gathering process. Inspired by the unique geometric structure of the cactus spine, we fabricated a bioinspired artificial fog collector consisting of cactus spines featuring barbs of different sizes and angles on the surfaces for water collection and a series of microcavities within microchannels inspired by Nepenthes Alata on the bottom to facilitate water flowing to the reservoir.

A lasso-based model to predict lateral lymph node metastasis in unifocal papillary thyroid carcinoma with central lymph node metastasis.

Objective: To screen the risk factors for lateral lymph node metastasis (LLNM) in unifocal papillary thyroid carcinoma (PTC) with central lymph node metastasis (CLNM) and create a corresponding model.

Methods: A retrospective analysis of 362 patients from our hospital was performed. All patients were randomized into training and validation groups in a ratio of 7:3.

Efficient Selection of the 2,4-Dichlorophenoxyacetic Acid Nanobody Gene from the Phage Library Constructed with Sorted Specific Cells and Expression in Plants to Confer Herbicide Resistance.

Immunomodulation in biotechnological processes requires an adequate level of specific, high-affinity recombinant antibodies expressed in the affected cells. Here, we report a new strategy to obtain a sensitive nanobody against the 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide. Unlike the previous methods that used total peripheral blood lymphocytes, specific peripheral lymphocytes stained with a fluorescein isothiocyanate-labeled 2,4-D coating antigen were isolated via fluorescence-activated cell sorting and used for phage display library construction.

Individuals with high autism traits show top-down attention bias towards threatening stimuli.

Individuals with autistic traits (AT) are widely distributed in the general population. Strengthening understanding of AT can provide a broader perspective for autism research as well as more accurate diagnosis and personalized treatment plans for clinical practice. Previous studies on attention bias among high-AT individuals have yielded inconsistent results, which may relate to different stages of attention.

Proanthocyanidins as the marker of amomum fruit from three botanical origins based on comprehensive profiling with LC-MS and GC-MS combined with chemometrics.

Introduction: Amomum fruit, also known as Sharen, serves as both a functional food and a traditional Chinese medicine with significant pharmacological activities. However, there are three botanical origins of Amomum fruit: Amomum villosum Lour. (AVL), Amomum villosum Lour.

Unraveling the Influence of Satellite-Observed Land Surface Temperature on High-Resolution Mapping of Ground-Level Ozone Using Interpretable Machine Learning.

Accurately mapping ground-level ozone concentrations at high spatiotemporal resolution (daily, 1 km) is essential for evaluating human exposure and conducting public health assessments. This requires identifying and understanding a proxy that is well-correlated with ground-level ozone variation and available with spatiotemporal high-resolution data. This study introduces a high-resolution ozone modeling method utilizing the XGBoost algorithm with satellite-derived land surface temperature (LST) as the primary predictor.

Metal ion and organic ligand disubstituted bimetallic metal-organic framework nanosheets for high-performance alkaline zinc-based batteries.

Herein, a disubstitution strategy of metal ions and organic ligands is employed to synthesize metal-organic framework (MOF) nanosheets with a three-dimensional (3D) porous structure and a highly active metal-sulfur (M-S, M = Co and Ni) region. The obtained MOFs//Zn batteries exhibit excellent electrochemical properties and the electrochemical reaction mechanism was elucidated through a series of characterizations.

Endothelial Birc3 promotes renal fibrosis through modulating Drp1-mediated mitochondrial fission via MAPK/PI3K/Akt pathway.

Renal fibrosis serves as the shared pathway in chronic kidney disease (CKD) progression towards end-stage renal disease (ESRD). Endothelial-mesenchymal transition (EndMT) is a vital mechanism leading to the generation of myofibroblasts, thereby contributing to the advancement of fibrogenesis. Baculoviral IAP Repeat Containing 3(Birc3) was identified as a crucial inhibitor of cell death and a significant mediator in inflammatory signaling and immunity.

Microbial nutrient limitation and carbon use efficiency changes under different degrees of litter decomposition.

Alpine ecosystems are important terrestrial carbon (C) pools, and microbial decomposers play a key role in litter decomposition. Microbial metabolic limitations in these ecosystems, however, remain unclear. The objectives of this study aim to elucidate the characteristics of microbial nutrient limitation and their C use efficiency (CUE), and to evaluate their response to environmental factors.

Nanobody Mediated Atrazine Resistance in Plants.

expression of recombinant antibodies has been proposed as a strategy for herbicide resistance but is not well advanced yet. Here, an atrazine nanobody gene fused with a green fluorescent protein tag was transformed to , which was confirmed with PCR, ELISA, and immunoblotting. High levels of nanobody accumulation were observed in the nucleus, cytoderm, and cytosol.

Bilateral axillo-breast approach robotic thyroglossal duct cyst resection in an adolescent: a case report and literature review.

Background: Thyroglossal duct cyst (TGDC) is a common congenital neck mass that is the most frequent cause of neck swelling in children. The traditional open Sistrunk procedure for TGDC often leaves a visible scar on the neck. Therefore, it is essential to consider the impact of neck scarring on the quality of life for children and adolescents.

3D-printed customised titanium mesh and bone ring technique for bone augmentation of combined bone defects in the aesthetic zone.

Purpose: Complex bone defects with a horizontal and vertical combined deficiency pose a clinical challenge in implant dentistry. This study reports the case of a young female patient who presented with a perforating bone defect in the aesthetic zone.

Materials And Methods: Based on prosthetically guided bone regeneration, virtual 3D bone augmentation was planned.

Insights into the cycling stability of manganese-based zinc-ion batteries: from energy storage mechanisms to capacity fluctuation and optimization strategies.

Manganese-based materials are considered as one of the most promising cathodes in zinc-ion batteries (ZIBs) for large-scale energy storage applications owing to their cost-effectiveness, natural availability, low toxicity, multivalent states, high operation voltage, and satisfactory capacity. However, their intricate energy storage mechanisms coupled with unsatisfactory cycling stability hinder their commercial applications. Previous reviews have primarily focused on optimization strategies for achieving high capacity and fast reaction kinetics, while overlooking capacity fluctuation and lacking a systematic discussion on strategies to enhance the cycling stability of these materials.

Large scale and oxygen vacancy VO porous thin sheets to enable high-performance zinc ion storage.

Herein, we report the first result of large scale and oxygen vacancy VO porous thin sheets assembled by a 3D interconnected nanoflake array framework, which is recorded as VO. The as-prepared VO was characterized by various methods and Zn intercalation/deintercalation and structural decomposition mechanisms were proposed based on X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).

Efficacy and safety of pyrotinib combined with albumin-bound paclitaxel as first-line treatment for HER2-positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuvant trastuzumab therapy: The stage 1 results of a single-arm, phase 2 prospective clinical trial.

Objective: It has been observed that the prognosis of patients with HER2-positive metastatic breast cancer has improved significantly with HER2-targeted agents. However, there is still a lack of evidence regarding first-line anti-HER2 treatment options for patients who have received adjuvant and/or neoadjuvant trastuzumab for HER2-positive metastatic breast cancer. Besides, there are no reliable markers that can predict the efficacy of anti-HER2 treatment in these patients.

Crystal engineering of bimetallic cobalt-based metal-organic framework nanosheets for high-performance aqueous rechargeable cobalt-zinc batteries.

Aqueous rechargeable Zn-based batteries (ARZBs) have attracted increasing attention as favorable candidates for energy storage systems due to their high security, environmental friendliness, and abundance of electrode materials. At present, the most widely reported materials used in cobalt-zinc (Co-Zn) batteries are cobalt-based oxides and their derivatives, however, they still exhibit low actual capacities and unsatisfactory cycle lives. Metal-organic frameworks (MOFs), as a new class of porous materials with high specific surface area and adjustable pore size, have attracted considerable attention in the field of energy storage.