Body mass index and glioma risk: A prospective multicenter study.

Background: The association between glioma risk and body mass index (BMI) remains obscure.

Methods: This study aimed to assess the association between glioma risk and BMI in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).

Oral Contraceptive and Glioma Risk: A Prospective Cohort Study and Meta-Analysis.

Background: Epidemiological evidence that glioma has a slight male predominance implies that factors associated with sex hormones may play a role in the development of glioma. The association between oral contraceptive (OC) use and glioma risk remains controversial.

Method: In the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial of 70,516 women in the USA, Cox proportional hazards regression analyses were adopted to calculate the crude and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

Parkinson's Disease Risk and Alcohol Intake: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.

The association between Parkinson's disease (PD) risk and alcohol intake is a controversial topic. To systematically assess the association between PD risk and alcohol intake. PubMed and Embase databases were searched for eligible studies with prospective design on PD risk and alcohol intake.

Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women.

Background: Results of stroke risk and coffee consumption are inconclusive. This study aimed to provide an updated systematic review and meta-analysis of the association between coffee consumption and stroke risk.

Method: Random-effects models were used to pool relative risk estimates (RRs) with 95% confidence intervals (CIs).

Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies.

Background: Inconsistent results of the association between fish consumption and stroke risk have been indicated in previous epidemiological studies. Therefore, we performed a meta-analysis of prospective cohort studies to estimate the impact of fish consumption on stroke risk.

Methods: The PubMed and EMBASE databases were searched through a computer search.

Down-regulated expression of aquaporin-4 in the cerebellum after status epilepticus.

Status epilepticus (SE) is a common neurological condition associated with high rates of mortality and permanent brain injury. SE usually leads to neuronal death which may be accompanied by edema, epileptogenesis and learning impairment. Aquaporin-4 (AQP4), is a transmembrane water channel protein in the neuropil of the central nervous system that has an important role in water transport in the brain; AQP4 expression is altered in many pathological conditions such as changes in the blood- brain barrier and/or astrocytic activation, including seizures.

Smoking and Glioma Risk: Evidence From a Meta-Analysis of 25 Observational Studies.

To systematically assess the relationship between smoking and glioma risk.A dose-response meta-analysis of case-control and cohort studies was performed. Pertinent studies were identified by searching database and reference lists.